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Catalog Number:
37853
CAS Number:
154598-52-4
Éfavirenz
Grade:
meets USP specification
Purity:
≥ 98 % (HPLC)
Synonym(s):
(4S)-6-chloro-4-(2-cyclopropyléthynyl)-1,4-dihydro-4-(trifluorométhyl)-2 H -3,1-benzoxazine-2-one
Temperature Sensitive
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Product Information

Efavirenz is a potent non-nucleoside reverse transcriptase inhibitor (NNRTI) widely utilized in the treatment of HIV-1 infection. This compound is recognized for its ability to effectively suppress viral replication, making it a crucial component of antiretroviral therapy regimens. Its unique structure, featuring a trifluoromethyl group and a cyclopropylethynyl moiety, contributes to its high selectivity and efficacy against the HIV virus. Efavirenz is often prescribed in combination with other antiretroviral agents to enhance therapeutic outcomes and improve patient adherence due to its once-daily dosing regimen.

In addition to its primary use in HIV treatment, Efavirenz has been the subject of extensive research for its potential applications in other viral infections and its role in pre-exposure prophylaxis (PrEP). The compound's favorable pharmacokinetic profile, including good oral bioavailability and a long half-life, allows for sustained antiviral activity, making it a valuable asset in both clinical and research settings. Researchers and healthcare professionals appreciate Efavirenz for its proven track record in improving patient outcomes and its ongoing relevance in the fight against HIV.

Synonyms
(4S)-6-chloro-4-(2-cyclopropyléthynyl)-1,4-dihydro-4-(trifluorométhyl)-2 H -3,1-benzoxazine-2-one
CAS Number
154598-52-4
Purity
≥ 98 % (HPLC)
Grade
meets USP specification
Molecular Formula
C 14 H 9 Cl F 3 NO 2
Molecular Weight
315.68
MDL Number
MFCD05662344
PubChem ID
3203
Appearance
Poudre blanche à presque blanche à cristal
Conditions
Conserver à < 0 °C
General Information
Synonyms
(4S)-6-chloro-4-(2-cyclopropyléthynyl)-1,4-dihydro-4-(trifluorométhyl)-2 H -3,1-benzoxazine-2-one
CAS Number
154598-52-4
Purity
≥ 98 % (HPLC)
Grade
meets USP specification
Molecular Formula
C 14 H 9 Cl F 3 NO 2
Molecular Weight
315.68
MDL Number
MFCD05662344
PubChem ID
3203
Appearance
Poudre blanche à presque blanche à cristal
Conditions
Conserver à < 0 °C
Properties
Additional property information coming soon!
-
Safety and Regulations
Hazmat
Non
Antibiotic
Non
DEA-regulated
Non
Warnings
-
Applications

Efavirenz is widely utilized in research focused on:

  • Antiretroviral Therapy: Primarily used in the treatment of HIV, Efavirenz is a key component of combination therapies, helping to suppress viral load and improve patient outcomes.
  • Pharmaceutical Development: Researchers leverage Efavirenz in the development of new antiviral drugs, studying its mechanisms and potential enhancements to improve efficacy and reduce side effects.
  • Clinical Trials: Efavirenz is frequently involved in clinical trials aimed at evaluating its effectiveness in various populations, including those with drug-resistant HIV strains.
  • Drug Interaction Studies: The chemical is used to assess interactions with other medications, providing valuable insights for healthcare providers in managing complex treatment regimens.
  • Pharmacokinetics Research: Researchers study the absorption, distribution, metabolism, and excretion of Efavirenz to optimize dosing strategies and improve therapeutic outcomes for patients.

Citations