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Catalog Number:
37605
CAS Number:
133550-35-3
Tyrphostin AG 494
Purity:
≥ 98% (HPLC)
Synonym(s):
(E-2-Cyano-3-(3,4-dihydroxyphenyl)-N-phenylacrylamide
Hazmat
Documents
$181.67 /20MG
Pack Size Availability Price
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Product Information

Tyrphostin AG 494 is a potent and selective inhibitor of receptor tyrosine kinases, particularly effective in the study of cancer biology and therapeutic development. This compound is recognized for its ability to modulate signal transduction pathways, making it invaluable in research focused on cell proliferation, differentiation, and apoptosis. Its unique structure, featuring a cyano group and a phenylprop-2-enamide backbone, enhances its binding affinity to target proteins, thereby providing researchers with a reliable tool for investigating the mechanisms of tumor growth and metastasis.

In practical applications, Tyrphostin AG 494 has shown promise in preclinical studies aimed at developing targeted cancer therapies. Its effectiveness in inhibiting specific kinases can lead to breakthroughs in personalized medicine, allowing for tailored treatment strategies that minimize side effects while maximizing therapeutic efficacy. Additionally, this compound can serve as a lead compound in drug discovery, offering a foundation for the development of novel anti-cancer agents. Researchers and industry professionals will find Tyrphostin AG 494 to be an essential addition to their toolkit for advancing cancer research and therapeutic innovation.

Synonyms
(E-2-Cyano-3-(3,4-dihydroxyphenyl)-N-phenylacrylamide
CAS Number
133550-35-3
Purity
≥ 98% (HPLC)
Molecular Formula
C16H12N2O3
Molecular Weight
280.28
MDL Number
MFCD00209863
PubChem ID
2055
Melting Point
249 °C (dec.)
Appearance
Light yellow to amber to dark green powder to crystal
Conditions
Store at 2 - 8 °C
General Information
Synonyms
(E-2-Cyano-3-(3,4-dihydroxyphenyl)-N-phenylacrylamide
CAS Number
133550-35-3
Purity
≥ 98% (HPLC)
Molecular Formula
C16H12N2O3
Molecular Weight
280.28
MDL Number
MFCD00209863
PubChem ID
2055
Melting Point
249 °C (dec.)
Appearance
Light yellow to amber to dark green powder to crystal
Conditions
Store at 2 - 8 °C
Properties
Additional property information coming soon!
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Safety and Regulations
Hazmat
Yes
Antibiotic
No
DEA-regulated
No
Warnings
-
Applications

Tyrphostin AG 494 is widely utilized in research focused on:

  • Cancer Research: This compound serves as a potent inhibitor of specific receptor tyrosine kinases, making it valuable in studying tumor growth and metastasis. Researchers can explore its effects on various cancer cell lines to develop targeted therapies.
  • Signal Transduction Studies: Tyrphostin AG 494 helps in understanding cellular signaling pathways by inhibiting key enzymes. This application is crucial for scientists investigating how cells communicate and respond to external stimuli.
  • Drug Development: Pharmaceutical companies leverage this compound to screen for potential drug candidates that can modulate kinase activity, leading to innovative treatments for diseases related to dysregulated signaling.
  • Neuroscience: The compound is also explored for its neuroprotective properties, offering insights into neurodegenerative diseases. Researchers can assess its impact on neuronal survival and function.
  • Biotechnology: In the field of biotechnology, Tyrphostin AG 494 is used to enhance the efficacy of biopharmaceuticals by modulating cell signaling, thus improving the yield and quality of biologics produced in cell cultures.

Citations