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🌟 NEW: Customizable Macrocyclic Peptide Libraries

Discover Peptide Hits Faster

With high-quality, customizable Macrocyclic Peptide (MCP) Libraries distributed by Chem-Impex

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  • Enhanced Diversity

    Access to 10,000+ unique peptides synthesized from over 60 α-, β-, and γ-amino acid building blocks (out of the 1,000's available)

  • Optimized Screening

    Compatible with phenotypic assays and mass spectrometry-based workflows

  • Support For Current Stage

    Choose from 1,000’s of building blocks at early stage discovery and hit-to-lead expansion

  • No Tags or Barcodes 

    For easy functional screens, as well as affinity-based selections

  • Greater Speed

    10x larger libraries, 4x faster iteration cycles

  • Proven Success

    Synthesized, delivered, and screened by NIH/NCATS

A New Way to Screen

Built by BRiTeCycle™, a synthesis platform developed by BRT Technologies, these MCP libraries allow for more rapid early-stage drug discovery, particularly hard-to-drug targets.

They offer extensive chemical diversity, flexible formats, rapid analog follow-up, and ready-to-screen usability, providing researchers with a new way to screen, helping streamline workflows wherever you are in your process, and accelerate the path from hit identification to lead optimization.

About the Libraries

All libraries are made-to-order to ensure they meet your specific requirements, and are ready for immediate use.

Key Features:

  • Minimum purity: ≥70%
  • Quantity per compound: 15 nmol
  • Synthesized from 1,000's of unique α-, β-, and γ-amino acid building blocks available at early stage discovery and hit-to-lead expansion
  • High membrane permeability and conformational constraint 
  • Compatible with phenotypic and mass spec-based assays
  • No tags or barcodes for easy functional screens, as well as affinity-based selections 

Customizable Formats:

  • Sizes: 2,300 or 10,000+ macrocyclic hexapeptides
  • Delivery: discrete compounds (dried or in DMSO) or deconvolutable pools, in 384-well plates
  • Custom plating and barcoding upon request
  • Custom analog libraries

Lead-Time:

  • 2,300 compound library: 2-3 weeks (approx.)
  • 10,000+ compound library: 3-4 weeks (approx.)

Follow-Up Support:

  • Resynthesis of up to 24 purified MCPs
  • Hit-to-lead expansion through custom follow-up libraries
Get Started

What’s BRiTeCycle™?

Developed by a team of BRT scientists with deep expertise in discovery chemistry, BRiTeCycle™ is a proprietary synthesis engine enabling structurally diverse, non-canonical macrocyclic peptides.

Despite its recent introduction, the platform has already demonstrated significant impact:

  • Enabling 10x larger libraries
  • 4x faster iteration cycles
  • 10,000 macrocycles synthesized, delivered, and screened by NIH/NCATS

Applications

What Makes BRiTeCycle™ MCP Libraries Special?

Support for Your Current Stage

Choose from 1,000’s of building blocks at early stage discovery and hit-to-lead expansion.

No Tags or Barcodes

For easy functional screens, as well as affinity-based selections.

Powerful Diversity

Explore 2,300 or 10,000+ macrocyclic hexapeptides synthesized from collections of 60+ unique α-, β-, and γ-amino acid building blocks—including N-alkylated and cyclic structures - out of the 1,000's that are commercially available.

Ready for Real Screens

Optimized for both phenotypic assays and mass spec-based workflows, these libraries give you the depth and selectivity to uncover novel hits—even in complex biological systems.

Flexible Formats

Choose between discrete compounds (dried or in DMSO) or deconvolutable pools. All available to deliver in 384-well plates.

Follow-up Support

Resynthesis of hit MCPs

Get Started

  1. Request a quote online. Request here.
  2. Book an online consultation with our scientific team to tailor the library to your assay and screening needs. Book here.
  3. Submit an order via PO and make a payment. 
  4. Receive your made-to-order library in as little as 2 weeks.

Frequently Asked Questions

Who can purchase these MCP libraries?

Only customers located within the United States and Canada can purchase these libraries.

What is BRT Technologies (BRT)?

BRT Biotechnologies was founded by Jane Liu, Gregory Copeland and a team of expert scientists with the vision of advancing drug discovery by providing high quality macrocycle libraries that enable rapid identification of promising drug leads. Leveraging decades of expertise in medicinal chemistry, BRT developed the innovative BRiTeCycle™ platform.

What makes these MCP libraries different? 

These MCP Libraries are built using the proprietary BRiTeCycle™ platform, enabling the creation of structurally diverse, non-canonical macrocyclic peptides. This approach offers:

  • Enhanced Diversity: Access to 10,000+ unique peptides synthesized from over 60 α-, β-, and γ-amino acid building blocks (out of the 1,000's available), including N-alkylated and cyclic structures.
  • Optimized Screening: Libraries designed for compatibility with both phenotypic assays and mass spectrometry-based workflows.
  • Rapid Turnaround: Made-to-order libraries with lead times as short as 2–3 weeks for smaller libraries.

What is BRiTeCycle™? 

BRiTeCycle™ is a novel synthesis engine developed by experienced medicinal chemists. It enables the creation of macrocyclic peptides beyond the capabilities of standard SPPS or mRNA display methods, expanding access to non-canonical structures and high-diversity scaffolds. This platform has already demonstrated significant impact, with 10,000 macrocycles synthesized, delivered, and screened by NIH/NCATS.

What is the purity of the compounds? 

Each compound is delivered at ≥70% purity, suitable for most screening applications. For follow-up studies requiring higher purity, resynthesis with full purification is available upon request.

How much material is provided per compound? 

Each compound is delivered with 15 nmol, which is standard for high-throughput screening. Larger quantities can be provided through resynthesis if needed.

Are custom formats or layouts available? 

Yes, libraries can be delivered in discrete or pooled formats, including 384-well plates. Custom plating and barcoding options are available upon request to suit your specific needs.

How does this ship? 

Can ship on dry ice, overnight.

What are the lead times? 
  • 2,300-compound library: Approximately 2–3 weeks
  • 10,000-compound library: Approximately 2–3 months

All libraries are made-to-order to ensure they meet your specific requirements.

Is pricing listed online? 

Pricing is not listed online. To receive a quote, please submit a request through our "Request a Quote" form. Introductory offers are available for early adopters.

How does fulfillment work? 

Orders are placed through Chem-Impex, and libraries ship directly from BRT Biotechnologies in Claremont, CA. Shipping options include overnight delivery on dry ice to maintain compound stability.

Can I talk to someone about library fit before ordering? 

Absolutely. Each inquiry includes a scientific consultation to help you choose the right library and support services tailored to your assay and screening needs.

Are these libraries suited for academic labs? 

Yes, these libraries are designed for use in biotech, pharma, and academic discovery. They are particularly useful for exploring novel mechanisms of action and targeting hard-to-drug proteins.

What is the return policy?

Due to the custom nature of these libraries, no cancellations, refunds, or returns are allowed once an order is placed.

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