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Catalog Number:
37615
CAS Number:
177036-94-1
Ambrisentan
Purity:
≥ 98% (HPLC)
Synonym(s):
(S)-2-[(4,6-Dimethylpyrimidin-2-yl)oxy]-3-methoxy-3,3-diphenylpropionic acid
Documents
$29.34 /20MG
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Product Information

Ambrisentan is a potent and selective endothelin receptor antagonist primarily used in the treatment of pulmonary arterial hypertension (PAH). This compound works by blocking the effects of endothelin-1, a peptide that causes blood vessels to constrict, thereby promoting vasodilation and improving blood flow. Its unique structure, featuring a pyrimidine ring and multiple aromatic groups, enhances its efficacy and selectivity, making it a valuable option in managing PAH. Researchers and healthcare professionals appreciate Ambrisentan for its ability to improve exercise capacity and delay clinical worsening in patients, offering a significant quality of life improvement.

In addition to its primary use in PAH, Ambrisentan is being explored for potential applications in other cardiovascular conditions and diseases characterized by vascular dysfunction. Its favorable pharmacokinetic profile allows for once-daily dosing, which enhances patient adherence to treatment regimens. With ongoing research, Ambrisentan holds promise for expanding its therapeutic applications, making it a compound of interest for both researchers and clinicians focused on innovative cardiovascular therapies.

Synonyms
(S)-2-[(4,6-Dimethylpyrimidin-2-yl)oxy]-3-methoxy-3,3-diphenylpropionic acid
CAS Number
177036-94-1
Purity
≥ 98% (HPLC)
Molecular Formula
C22H22N2O4
Molecular Weight
378.43
MDL Number
MFCD09842330
PubChem ID
197712
Melting Point
178 °C (dec.)
Appearance
White to almost white powder to crystal
Optical Rotation
[a]20D = 170 - 176 ° (C=0.5 in MeOH)
Conditions
Store at 2 - 8 °C
General Information
Synonyms
(S)-2-[(4,6-Dimethylpyrimidin-2-yl)oxy]-3-methoxy-3,3-diphenylpropionic acid
CAS Number
177036-94-1
Purity
≥ 98% (HPLC)
Molecular Formula
C22H22N2O4
Molecular Weight
378.43
MDL Number
MFCD09842330
PubChem ID
197712
Melting Point
178 °C (dec.)
Appearance
White to almost white powder to crystal
Optical Rotation
[a]20D = 170 - 176 ° (C=0.5 in MeOH)
Conditions
Store at 2 - 8 °C
Properties
Additional property information coming soon!
-
Safety and Regulations
Hazmat
No
Antibiotic
No
DEA-regulated
No
Warnings
-
Applications

Ambrisentan is widely utilized in research focused on:

  • Treatment of Pulmonary Arterial Hypertension (PAH): This compound is primarily used as a medication to improve exercise capacity and delay disease progression in patients with PAH, providing significant benefits in quality of life.
  • Vascular Research: Researchers use Ambrisentan to study its effects on vascular smooth muscle cells, helping to understand mechanisms of vascular remodeling and potential therapeutic targets for cardiovascular diseases.
  • Drug Interaction Studies: It serves as a valuable tool in pharmacology for assessing drug-drug interactions, particularly in the context of medications that affect liver enzymes, aiding in safer medication management.
  • Clinical Trials: Ambrisentan is frequently included in clinical trials aimed at evaluating new treatment protocols for PAH and other related conditions, contributing to advancements in medical therapies.
  • Comparative Effectiveness Research: Its unique properties allow researchers to compare its efficacy and safety against other endothelin receptor antagonists, helping to refine treatment strategies for patients.

Citations