🌟 99% Happy customers

📦 Same-day shipping on in-stock items

Catalog Number:
37681
CAS Number:
157212-55-0
Bosentan monohydrate
Purity:
≥ 98% (HPLC)
Synonym(s):
4-(tert-Butyl)-N-[6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)[2,2'-bipyrimidin]-4-yl]benzenesulfonamide monohydrate, 4-tert-Butyl-N-[6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)-2-(pyrimidin-2-yl)pyrimidin-4-yl]benzenesulfonamide monohydrate
Documents
$73.71 /25MG
Pack Size Availability Price
Request Bulk Quote
Product Information

Bosentan monohydrate is a potent dual endothelin receptor antagonist, primarily utilized in the treatment of pulmonary arterial hypertension (PAH). This compound works by inhibiting the effects of endothelin-1, a peptide that causes blood vessels to constrict, thereby promoting vasodilation and improving blood flow. Its unique structure allows for effective modulation of vascular resistance, making it a valuable therapeutic agent in managing PAH and improving exercise capacity in affected patients.

In addition to its primary use in pharmaceuticals, Bosentan monohydrate has potential applications in research settings, particularly in studies focused on cardiovascular health and endothelial function. Its ability to selectively target endothelin receptors positions it as a critical compound for exploring new treatment avenues for various vascular disorders. Researchers and industry professionals can leverage Bosentan monohydrate's properties to develop innovative therapies and enhance understanding of endothelial biology.

Synonyms
4-(tert-Butyl)-N-[6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)[2,2'-bipyrimidin]-4-yl]benzenesulfonamide monohydrate, 4-tert-Butyl-N-[6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)-2-(pyrimidin-2-yl)pyrimidin-4-yl]benzenesulfonamide monohydrate
CAS Number
157212-55-0
Purity
≥ 98% (HPLC)
Molecular Formula
C27H29N5O6S·H2O
Molecular Weight
569.64
MDL Number
MFCD09751188
PubChem ID
185462
Melting Point
111 - 113 °C
Appearance
White to light yellow powder to crystal
Conditions
Store at 2 - 8 °C
General Information
Synonyms
4-(tert-Butyl)-N-[6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)[2,2'-bipyrimidin]-4-yl]benzenesulfonamide monohydrate, 4-tert-Butyl-N-[6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)-2-(pyrimidin-2-yl)pyrimidin-4-yl]benzenesulfonamide monohydrate
CAS Number
157212-55-0
Purity
≥ 98% (HPLC)
Molecular Formula
C27H29N5O6S·H2O
Molecular Weight
569.64
MDL Number
MFCD09751188
PubChem ID
185462
Melting Point
111 - 113 °C
Appearance
White to light yellow powder to crystal
Conditions
Store at 2 - 8 °C
Properties
Additional property information coming soon!
-
Safety and Regulations
Hazmat
No
Antibiotic
No
DEA-regulated
No
Warnings
-
Applications

Bosentan monohydrate is widely utilized in research focused on:

  • Treatment of Pulmonary Arterial Hypertension (PAH): This compound is primarily used in the pharmaceutical industry to manage PAH, helping to improve exercise capacity and quality of life for patients.
  • Cardiovascular Research: Researchers employ bosentan monohydrate to study its effects on cardiovascular health, particularly in understanding the mechanisms of vascular remodeling and endothelial function.
  • Combination Therapies: It is often investigated in combination with other medications to enhance therapeutic outcomes in patients with heart failure or other cardiovascular conditions.
  • Drug Development: The compound serves as a model in drug formulation studies, aiding in the development of new therapies targeting similar pathways in vascular diseases.
  • Clinical Trials: Bosentan monohydrate is frequently used in clinical trials to evaluate its efficacy and safety profile, contributing to advancements in treatment protocols for various cardiovascular disorders.

Citations