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Catalog Number:
37717
CAS Number:
123318-82-1
Clofarabine
Purity:
99 - 101% (Assay, on dry basis)
Synonym(s):
2-Chloro-9-(2-deoxy-2-fluoro-ß-D-arabinofuranosyl)adenine
Documents
$35.15 /20MG
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Product Information

Clofarabine is a potent nucleoside analog primarily utilized in the treatment of acute lymphoblastic leukemia (ALL) and other hematological malignancies. This compound exhibits a unique mechanism of action, inhibiting DNA synthesis and promoting apoptosis in cancer cells, making it a valuable therapeutic agent in oncology. Its structural features, including the fluorine and chloropurine moieties, enhance its efficacy and selectivity, allowing for effective treatment regimens with potentially fewer side effects compared to traditional chemotherapeutics.

Researchers and healthcare professionals appreciate Clofarabine for its ability to overcome resistance mechanisms often seen in cancer therapies. It has been successfully incorporated into combination therapies, demonstrating improved outcomes in patients with relapsed or refractory ALL. Furthermore, ongoing studies continue to explore its applications in other malignancies, highlighting its versatility and potential in expanding treatment options for challenging cases. Clofarabine stands out as a critical tool in modern cancer treatment, offering hope for improved patient outcomes.

Synonyms
2-Chloro-9-(2-deoxy-2-fluoro-ß-D-arabinofuranosyl)adenine
CAS Number
123318-82-1
Purity
99 - 101% (Assay, on dry basis)
Molecular Formula
C10H11ClFN5O3
Molecular Weight
303.68
MDL Number
MFCD00871077
PubChem ID
354624
Melting Point
225 - 230 °C
Appearance
White to off-white crystalline powder
Optical Rotation
[a]D20 = 38 - 42 ° (C=0.5 in DMF)
Conditions
Store at 2 - 8 °C
General Information
Synonyms
2-Chloro-9-(2-deoxy-2-fluoro-ß-D-arabinofuranosyl)adenine
CAS Number
123318-82-1
Purity
99 - 101% (Assay, on dry basis)
Molecular Formula
C10H11ClFN5O3
Molecular Weight
303.68
MDL Number
MFCD00871077
PubChem ID
354624
Melting Point
225 - 230 °C
Appearance
White to off-white crystalline powder
Optical Rotation
[a]D20 = 38 - 42 ° (C=0.5 in DMF)
Conditions
Store at 2 - 8 °C
Properties
Additional property information coming soon!
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Safety and Regulations
Hazmat
No
Antibiotic
No
DEA-regulated
No
Warnings
-
Applications

Clofarabine is widely utilized in research focused on

  • Pediatric Oncology: Primarily used in the treatment of acute lymphoblastic leukemia (ALL) in children, providing an effective option for patients who have not responded to other therapies.
  • Combination Therapy: Often combined with other chemotherapeutic agents to enhance efficacy and overcome drug resistance, making it a valuable tool in complex treatment regimens.
  • Clinical Trials: Frequently involved in clinical trials aimed at improving treatment protocols for various hematological malignancies, helping researchers develop better therapeutic strategies.
  • Pharmaceutical Development: Serves as a reference compound in the development of new anti-cancer drugs, aiding in the understanding of drug interactions and mechanisms of action.
  • Research on Mechanisms of Action: Used in studies exploring its unique mechanism that targets both DNA synthesis and repair pathways, contributing to advancements in cancer treatment research.

Citations