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Catalog Number:
37801
CAS Number:
120011-70-3
Donepezil hydrochloride
Purity:
≥ 98% (Assay by titration, HPLC)
Synonym(s):
2-(1-Benzyl-4-piperidylmethyl)-5,6-dimethoxy-1-indanone hydrochloride
Documents
$140.11 /1G
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Product Information

Donepezil hydrochloride is a potent and selective reversible inhibitor of the enzyme acetylcholinesterase, primarily utilized in the treatment of Alzheimer's disease. This compound enhances cholinergic neurotransmission by preventing the breakdown of acetylcholine, thereby improving cognitive function and memory in patients. Its unique structure, featuring a benzylpiperidine moiety, contributes to its efficacy and selectivity, making it a preferred choice in neuropharmacology.

In addition to its primary application in Alzheimer's therapy, Donepezil hydrochloride is also being explored for potential uses in other cognitive disorders and conditions characterized by cholinergic deficits. Researchers appreciate its favorable pharmacokinetic profile, which allows for once-daily dosing, enhancing patient compliance. The compound's ability to cross the blood-brain barrier effectively positions it as a valuable tool in both clinical and research settings, paving the way for advancements in neurodegenerative disease management.

Synonyms
2-(1-Benzyl-4-piperidylmethyl)-5,6-dimethoxy-1-indanone hydrochloride
CAS Number
120011-70-3
Purity
≥ 98% (Assay by titration, HPLC)
Molecular Formula
C24H29NO3·HCl
Molecular Weight
415.96
MDL Number
MFCD17215939
PubChem ID
5741
Melting Point
225 °C
Appearance
White to almost white powder to crystal
Conditions
Store at RT
General Information
Synonyms
2-(1-Benzyl-4-piperidylmethyl)-5,6-dimethoxy-1-indanone hydrochloride
CAS Number
120011-70-3
Purity
≥ 98% (Assay by titration, HPLC)
Molecular Formula
C24H29NO3·HCl
Molecular Weight
415.96
MDL Number
MFCD17215939
PubChem ID
5741
Melting Point
225 °C
Appearance
White to almost white powder to crystal
Conditions
Store at RT
Properties
Additional property information coming soon!
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Safety and Regulations
Hazmat
No
Antibiotic
No
DEA-regulated
No
Warnings
-
Applications

Donepezil hydrochloride is widely utilized in research focused on:

  • Alzheimer's Disease Treatment: This compound is primarily used in the treatment of Alzheimer's disease, helping to improve cognitive function and slow the progression of symptoms in patients.
  • Neuropharmacology Studies: Researchers use donepezil hydrochloride to study its effects on neurotransmitter systems, particularly acetylcholine, which is crucial for memory and learning.
  • Drug Interaction Research: It serves as a valuable tool in pharmacological studies to investigate interactions with other medications, aiding in the development of safer treatment protocols.
  • Clinical Trials: Donepezil hydrochloride is frequently involved in clinical trials aimed at evaluating new therapies for cognitive disorders, providing insights into its efficacy and safety.
  • Formulation Development: The compound is also studied for its formulation in various delivery systems, enhancing patient compliance and therapeutic outcomes.

Citations