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Catalog Number:
37847
CAS Number:
209216-23-9
Entecavir monohydrate
Purity:
≥ 98% (Assay, HPLC)
Synonym(s):
9-[(1S,3R,4S)-4-Hydroxy-3-(hydroxymethyl)-2-methylenecyclopentyl]guanine monohydrate
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$68.20 /50MG
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Product Information

Entecavir monohydrate is a potent antiviral agent primarily used in the treatment of chronic hepatitis B virus (HBV) infections. This compound functions as a nucleoside analogue, effectively inhibiting viral replication by targeting the reverse transcriptase enzyme, making it a critical option for patients with HBV-related liver disease. Its unique structure allows for high selectivity against HBV, minimizing the risk of resistance compared to other antiviral medications.

In addition to its primary use in hepatitis B treatment, Entecavir monohydrate is also being explored for potential applications in other viral infections, showcasing its versatility in antiviral therapy. Researchers appreciate its favorable pharmacokinetic profile, which supports once-daily dosing and enhances patient compliance. With ongoing studies, Entecavir monohydrate holds promise for broader applications in virology, making it a valuable compound for both clinical and research settings.

Synonyms
9-[(1S,3R,4S)-4-Hydroxy-3-(hydroxymethyl)-2-methylenecyclopentyl]guanine monohydrate
CAS Number
209216-23-9
Purity
≥ 98% (Assay, HPLC)
Molecular Formula
C12H15N5O3·H2O
Molecular Weight
295.3
MDL Number
MFCD09754448
PubChem ID
135761783
Melting Point
259 °C (dec.)
Appearance
White to almost white powder to crystal
Optical Rotation
[a]20D = 34 - 38 ° (C=0.25 in H2O) (calcd. on anh. substance)
Conditions
Store at 2 - 8 °C
General Information
Synonyms
9-[(1S,3R,4S)-4-Hydroxy-3-(hydroxymethyl)-2-methylenecyclopentyl]guanine monohydrate
CAS Number
209216-23-9
Purity
≥ 98% (Assay, HPLC)
Molecular Formula
C12H15N5O3·H2O
Molecular Weight
295.3
MDL Number
MFCD09754448
PubChem ID
135761783
Melting Point
259 °C (dec.)
Appearance
White to almost white powder to crystal
Optical Rotation
[a]20D = 34 - 38 ° (C=0.25 in H2O) (calcd. on anh. substance)
Conditions
Store at 2 - 8 °C
Properties
Additional property information coming soon!
-
Safety and Regulations
Hazmat
No
Antibiotic
No
DEA-regulated
No
Warnings
-
Applications

Entecavir monohydrate is widely utilized in research focused on:

  • Antiviral Treatments: This compound is primarily used in the treatment of chronic hepatitis B virus infections, providing a potent option for patients who need effective antiviral therapy.
  • Pharmaceutical Development: It serves as a key ingredient in drug formulations, allowing pharmaceutical companies to develop effective therapies with improved bioavailability and patient compliance.
  • Clinical Research: Researchers use it in clinical trials to evaluate its efficacy and safety, contributing to the understanding of hepatitis B management and treatment protocols.
  • Combination Therapies: Entecavir monohydrate is often investigated in combination with other antiviral agents to enhance treatment outcomes and reduce viral resistance.
  • Biotechnology Applications: In the biotech industry, it is used in the development of diagnostic tools and assays for hepatitis B, aiding in the monitoring and management of the disease.

Citations