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Catalog Number:
37717
CAS Number:
123318-82-1
Clofarabine
Purity:
99 - 101 % (dosage, sur une base sèche)
Synonym(s):
2-Chloro-9-(2-désoxy-2-fluoro-ß-D-arabinofuranosyl)adénine
Documents
$35.15 /20 mg
Taille
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Product Information

Clofarabine is a potent nucleoside analog primarily utilized in the treatment of acute lymphoblastic leukemia (ALL) and other hematological malignancies. This compound exhibits a unique mechanism of action, inhibiting DNA synthesis and promoting apoptosis in cancer cells, making it a valuable therapeutic agent in oncology. Its structural features, including the fluorine and chloropurine moieties, enhance its efficacy and selectivity, allowing for effective treatment regimens with potentially fewer side effects compared to traditional chemotherapeutics.

Researchers and healthcare professionals appreciate Clofarabine for its ability to overcome resistance mechanisms often seen in cancer therapies. It has been successfully incorporated into combination therapies, demonstrating improved outcomes in patients with relapsed or refractory ALL. Furthermore, ongoing studies continue to explore its applications in other malignancies, highlighting its versatility and potential in expanding treatment options for challenging cases. Clofarabine stands out as a critical tool in modern cancer treatment, offering hope for improved patient outcomes.

Synonyms
2-Chloro-9-(2-désoxy-2-fluoro-ß-D-arabinofuranosyl)adénine
CAS Number
123318-82-1
Purity
99 - 101 % (dosage, sur une base sèche)
Molecular Formula
C10H11ClFN5O3
Molecular Weight
303.68
MDL Number
MFCD00871077
PubChem ID
354624
Melting Point
225 - 230 °C
Appearance
Poudre cristalline blanche à blanc cassé
Optical Rotation
[a] D 20 = 38 - 42 ° (C = 0,5 dans DMF)
Conditions
Conserver entre 2 et 8 °C
General Information
Synonyms
2-Chloro-9-(2-désoxy-2-fluoro-ß-D-arabinofuranosyl)adénine
CAS Number
123318-82-1
Purity
99 - 101 % (dosage, sur une base sèche)
Molecular Formula
C10H11ClFN5O3
Molecular Weight
303.68
MDL Number
MFCD00871077
PubChem ID
354624
Melting Point
225 - 230 °C
Appearance
Poudre cristalline blanche à blanc cassé
Optical Rotation
[a] D 20 = 38 - 42 ° (C = 0,5 dans DMF)
Conditions
Conserver entre 2 et 8 °C
Properties
Additional property information coming soon!
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Safety and Regulations
Hazmat
Non
Antibiotic
Non
DEA-regulated
Non
Warnings
-
Applications

Clofarabine is widely utilized in research focused on

  • Pediatric Oncology: Primarily used in the treatment of acute lymphoblastic leukemia (ALL) in children, providing an effective option for patients who have not responded to other therapies.
  • Combination Therapy: Often combined with other chemotherapeutic agents to enhance efficacy and overcome drug resistance, making it a valuable tool in complex treatment regimens.
  • Clinical Trials: Frequently involved in clinical trials aimed at improving treatment protocols for various hematological malignancies, helping researchers develop better therapeutic strategies.
  • Pharmaceutical Development: Serves as a reference compound in the development of new anti-cancer drugs, aiding in the understanding of drug interactions and mechanisms of action.
  • Research on Mechanisms of Action: Used in studies exploring its unique mechanism that targets both DNA synthesis and repair pathways, contributing to advancements in cancer treatment research.

Citations