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Catalog Number:
07844
CAS Number:
170850-75-6
Boc-L-trans-4-hydroxyproline tert-butyl ester
Purity:
≥ 98% (HPLC)
Synonym(s):
Boc-L-Hyp-OtBu, Boc-(2S,4R)-4-hydroxypyrrolidine-2-carboxylic acid tert-butyl ester
Documents
$93.14 /250MG
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Product Information

Boc-L-trans-4-hydroxyproline tert-butyl ester is a versatile compound widely utilized in the fields of organic synthesis and pharmaceutical research. This compound serves as a valuable building block for the synthesis of various peptides and biologically active molecules, particularly those that require the incorporation of hydroxyproline residues. Its unique structure, featuring a tert-butyl ester group, enhances its stability and solubility, making it an ideal candidate for applications in medicinal chemistry and drug development. Researchers often leverage its properties to create more complex structures, facilitating the exploration of new therapeutic agents.

In addition to its role in peptide synthesis, Boc-L-trans-4-hydroxyproline tert-butyl ester is also employed in the development of biomaterials and as a chiral auxiliary in asymmetric synthesis. Its ability to provide stereochemical control makes it a preferred choice for chemists aiming to produce enantiomerically pure compounds. The compound's favorable characteristics, such as ease of handling and compatibility with various reaction conditions, further underscore its significance in both academic and industrial settings.

Synonyms
Boc-L-Hyp-OtBu, Boc-(2S,4R)-4-hydroxypyrrolidine-2-carboxylic acid tert-butyl ester
CAS Number
170850-75-6
Purity
≥ 98% (HPLC)
Molecular Formula
C14H25NO5
Molecular Weight
287.36
MDL Number
MFCD01318729
PubChem ID
18967914
Appearance
White to off-white solid
Optical Rotation
[a]D20 = -75 ± 2 º (C=1 in MeOH)
Conditions
Store at 0 - 8 °C
General Information
Synonyms
Boc-L-Hyp-OtBu, Boc-(2S,4R)-4-hydroxypyrrolidine-2-carboxylic acid tert-butyl ester
CAS Number
170850-75-6
Purity
≥ 98% (HPLC)
Molecular Formula
C14H25NO5
Molecular Weight
287.36
MDL Number
MFCD01318729
PubChem ID
18967914
Appearance
White to off-white solid
Optical Rotation
[a]D20 = -75 ± 2 º (C=1 in MeOH)
Conditions
Store at 0 - 8 °C
Properties
Additional property information coming soon!
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Safety and Regulations
Hazmat
No
Antibiotic
No
DEA-regulated
No
Warnings
-
Applications

Boc-L-trans-4-hydroxyproline tert-butyl ester is widely utilized in research focused on:

  • Peptide Synthesis: This compound serves as a key building block in the synthesis of peptides, particularly in the development of bioactive peptides that can be used in pharmaceuticals.
  • Drug Development: It plays a significant role in medicinal chemistry, where it is used to modify drug candidates to enhance their stability and bioavailability.
  • Protein Engineering: The compound is valuable in the field of protein engineering, allowing researchers to create modified proteins with improved properties for therapeutic applications.
  • Biotechnology: In biotechnological applications, it is used to produce modified amino acids that can improve the efficacy of biopharmaceuticals.
  • Research in Structural Biology: This chemical is also employed in structural biology studies, helping scientists understand protein structures and interactions, which is crucial for drug design.

Citations