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Catalog Number:
11183
CAS Number:
214852-45-6
Fmoc-cis-D-4-hydroxyproline
Purity:
≥ 98% (HPLC)
Synonym(s):
Fmoc-D-cis-Hyp-OH, Fmoc-(2R,4R-4-Hydroxypyrrolidine-2-carboxylic acid
Documents
$65.40 /100MG
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Product Information

Fmoc-cis-D-4-hydroxyproline is a versatile amino acid derivative widely utilized in peptide synthesis and drug development. This compound features a fluorenylmethoxycarbonyl (Fmoc) protecting group, which is essential for the selective protection of amines during the synthesis process. Its unique cis configuration enhances the structural diversity of peptides, making it a valuable building block in the design of bioactive compounds. Researchers appreciate its ability to facilitate the incorporation of hydroxyl groups into peptides, which can significantly influence the biological activity and stability of the resulting molecules.

In the pharmaceutical industry, Fmoc-cis-D-4-hydroxyproline is particularly relevant for the development of peptide-based therapeutics, including those targeting specific receptors or enzymes. Its application extends to the synthesis of cyclic peptides and peptidomimetics, where the incorporation of this compound can improve binding affinity and selectivity. With its favorable properties and practical applications, Fmoc-cis-D-4-hydroxyproline stands out as an essential tool for researchers and professionals aiming to innovate in peptide chemistry and drug discovery.

Synonyms
Fmoc-D-cis-Hyp-OH, Fmoc-(2R,4R-4-Hydroxypyrrolidine-2-carboxylic acid
CAS Number
214852-45-6
Purity
≥ 98% (HPLC)
Molecular Formula
C20H19NO5
Molecular Weight
353.4
MDL Number
MFCD01318735
PubChem ID
3618049
Appearance
White solid
Optical Rotation
[a]D25 = +38 ± 2º (C=1 in DMF)
Conditions
Store at 0-8 °C
General Information
Synonyms
Fmoc-D-cis-Hyp-OH, Fmoc-(2R,4R-4-Hydroxypyrrolidine-2-carboxylic acid
CAS Number
214852-45-6
Purity
≥ 98% (HPLC)
Molecular Formula
C20H19NO5
Molecular Weight
353.4
MDL Number
MFCD01318735
PubChem ID
3618049
Appearance
White solid
Optical Rotation
[a]D25 = +38 ± 2º (C=1 in DMF)
Conditions
Store at 0-8 °C
Properties
Additional property information coming soon!
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Safety and Regulations
Hazmat
No
Antibiotic
No
DEA-regulated
No
Warnings
-
Applications

Fmoc-cis-D-4-hydroxyproline is widely utilized in research focused on:

  • Peptide Synthesis: This compound serves as a key building block in the synthesis of peptides, particularly in solid-phase peptide synthesis, allowing for the incorporation of unique structural features.
  • Drug Development: Its ability to stabilize peptide structures makes it valuable in the pharmaceutical industry for developing new drugs, especially those targeting specific proteins.
  • Bioconjugation: Fmoc-cis-D-4-hydroxyproline is used in bioconjugation techniques, facilitating the attachment of biomolecules to surfaces or other molecules, enhancing drug delivery systems.
  • Protein Engineering: Researchers leverage this compound in protein engineering to modify protein properties, improving their stability and functionality in various applications.
  • Research on Collagen Mimics: Its structural similarity to proline allows it to be used in studies aimed at developing collagen mimetics, which have applications in tissue engineering and regenerative medicine.

Citations