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Catalog Number:
12621
CAS Number:
229180-64-7
Fmoc-4-(phosphonomethyl)-L-phenylalanine
Purity:
≥ 98% (HPLC)
Synonym(s):
Fmoc-L-Phe(4-CH2PO3H2)-OH
Documents
$154.43 /100MG
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Product Information

Fmoc-4-(phosphonomethyl)-L-phenylalanine is a versatile amino acid derivative widely utilized in peptide synthesis and drug development. This compound features a unique phosphonomethyl group that enhances its reactivity, making it an excellent choice for researchers focused on creating phosphonate-containing peptides. Its Fmoc (fluorenylmethyloxycarbonyl) protecting group allows for easy incorporation into peptide chains, facilitating the synthesis of complex biomolecules. The compound's ability to mimic natural amino acids while introducing phosphonate functionalities opens new avenues in medicinal chemistry, particularly in the design of inhibitors for enzymes and receptors.

Researchers in the pharmaceutical industry can leverage Fmoc-4-(phosphonomethyl)-L-phenylalanine for developing targeted therapies and studying biochemical pathways. Its application extends to the synthesis of peptide-based drugs that require enhanced stability and bioactivity. The compound's unique properties not only improve the efficacy of therapeutic agents but also provide a strategic advantage in the competitive landscape of drug discovery. With its robust profile, this amino acid derivative is an essential tool for advancing research and innovation in peptide chemistry.

Synonyms
Fmoc-L-Phe(4-CH2PO3H2)-OH
CAS Number
229180-64-7
Purity
≥ 98% (HPLC)
Molecular Formula
C25H24NO7P
Molecular Weight
481.41
MDL Number
MFCD00235901
PubChem ID
4111219
Appearance
White to yellow powder/solid
Optical Rotation
[a]D25 = -12 ± 9 ° (C=1 in DMF) [a]D25 = -2 ± 1 ° (C=1 in 1N HCl)
Conditions
Store at 0 - 8 °C
General Information
Synonyms
Fmoc-L-Phe(4-CH2PO3H2)-OH
CAS Number
229180-64-7
Purity
≥ 98% (HPLC)
Molecular Formula
C25H24NO7P
Molecular Weight
481.41
MDL Number
MFCD00235901
PubChem ID
4111219
Appearance
White to yellow powder/solid
Optical Rotation
[a]D25 = -12 ± 9 ° (C=1 in DMF) [a]D25 = -2 ± 1 ° (C=1 in 1N HCl)
Conditions
Store at 0 - 8 °C
Properties
Additional property information coming soon!
-
Safety and Regulations
Hazmat
No
Antibiotic
No
DEA-regulated
No
Warnings
-
Applications

Fmoc-4-(phosphonomethyl)-L-phenylalanine is widely utilized in research focused on:

  • Peptide Synthesis: This compound is an essential building block in the synthesis of peptides, particularly in solid-phase peptide synthesis, allowing researchers to create complex peptides with high purity and yield.
  • Drug Development: Its unique phosphonomethyl group enhances the bioactivity of peptides, making it valuable in the pharmaceutical industry for developing new drugs targeting specific diseases.
  • Bioconjugation: The chemical serves as a versatile linker in bioconjugation applications, enabling the attachment of peptides to various biomolecules, which is crucial in creating targeted therapies and diagnostics.
  • Research in Cancer Therapy: Its properties facilitate the design of peptide-based inhibitors that can effectively target cancer cells, providing a promising avenue for cancer treatment research.
  • Protein Engineering: This compound is used in modifying proteins to enhance their stability and functionality, which is particularly beneficial in biotechnological applications.

Citations