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Catalog Number:
24550
CAS Number:
77377-52-7
N-(tert-Butyldimethylsilyl)-N-methyltrifluoracetamide
Purity:
≥ 99% (GC)
Synonym(s):
MTBSTFA
Hazmat
Documents
$55.00 /5G
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Product Information

N-(tert-Butyldimethylsilyl)-N-methyltrifluoracetamide is a versatile reagent widely utilized in organic synthesis and analytical chemistry. This compound serves as a powerful protecting group for amines and carboxylic acids, enabling chemists to selectively modify functional groups without interfering with other reactive sites. Its unique trifluoroacetamide moiety enhances stability and solubility, making it an ideal choice for various reactions, including peptide synthesis and the preparation of complex organic molecules. Researchers appreciate its ability to facilitate the purification and characterization of compounds, particularly in the development of pharmaceuticals and agrochemicals.

Moreover, N-(tert-Butyldimethylsilyl)-N-methyltrifluoracetamide exhibits excellent compatibility with a range of solvents and reaction conditions, allowing for greater flexibility in experimental design. Its distinctive properties not only streamline synthetic pathways but also improve yields and purity of the final products. This compound is essential for professionals seeking reliable and efficient solutions in their chemical processes, making it a valuable addition to any laboratory focused on advanced organic synthesis.

Synonyms
MTBSTFA
CAS Number
77377-52-7
Purity
≥ 99% (GC)
Molecular Formula
C9H18F3NOSi
Molecular Weight
241.33
MDL Number
MFCD00009671
PubChem ID
2724275
Density
1.036 g/mL at 25 °C
Appearance
Clear colorless liquid
Boiling Point
172 - 175 °C
Refractive Index
n20/D 1.402
Conditions
Store at 0 - 8 °C
General Information
Synonyms
MTBSTFA
CAS Number
77377-52-7
Purity
≥ 99% (GC)
Molecular Formula
C9H18F3NOSi
Molecular Weight
241.33
MDL Number
MFCD00009671
PubChem ID
2724275
Density
1.036 g/mL at 25 °C
Appearance
Clear colorless liquid
Boiling Point
172 - 175 °C
Refractive Index
n20/D 1.402
Conditions
Store at 0 - 8 °C
Properties
Additional property information coming soon!
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Safety and Regulations
Hazmat
Yes
Antibiotic
No
DEA-regulated
No
Warnings
-
Applications

N-(tert-Butyldimethylsilyl)-N-methyltrifluoracetamide is widely utilized in research focused on:

  • Organic Synthesis: This compound serves as a versatile protecting group for amines, allowing chemists to selectively modify other functional groups without affecting the amine. This is particularly useful in complex organic synthesis where multiple reactions are involved.
  • Analytical Chemistry: It is employed as a derivatizing agent in gas chromatography-mass spectrometry (GC-MS) to enhance the volatility and detectability of polar compounds. This application is crucial for environmental analysis and food safety testing.
  • Pharmaceutical Development: The compound is used in the synthesis of various pharmaceuticals, facilitating the formation of complex structures while improving the stability of intermediates during the drug development process.
  • Material Science: It finds applications in the development of silicone-based materials, contributing to the production of coatings and sealants that require enhanced thermal and chemical resistance.
  • Research in Fluorinated Compounds: This chemical is valuable in the study of fluorinated organic compounds, providing insights into their behavior and interactions, which is essential for developing new materials with specific properties.

Citations