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Catalog Number:
29726
CAS Number:
1219184-52-7, 460751-69-3
Fmoc-5-methoxy-L-tryptophan
Purity:
≥ 98.5% (Chiral HPLC)
Synonym(s):
Fmoc-L-Trp(5-OMe)-OH
Documents
$135.00 /25MG
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Product Information

Fmoc-5-methoxy-L-tryptophan is a versatile amino acid derivative widely used in peptide synthesis and pharmaceutical research. This compound features a fluorenylmethoxycarbonyl (Fmoc) protecting group, which is essential for the selective protection of amino groups during solid-phase peptide synthesis. Its unique structure not only enhances the stability of the peptide chain but also facilitates the introduction of the 5-methoxy tryptophan residue, known for its role in enhancing the bioactivity of peptides. Researchers and industry professionals utilize Fmoc-5-methoxy-L-tryptophan in the development of bioactive peptides, which have applications in drug discovery, particularly in the fields of oncology and neurology.

The compound's ability to improve solubility and bioavailability makes it an attractive choice for formulating therapeutic peptides. Additionally, its compatibility with various coupling reagents and solid supports streamlines the synthesis process, allowing for efficient production of complex peptide sequences. With its proven track record in enhancing peptide performance, Fmoc-5-methoxy-L-tryptophan stands out as a valuable tool for researchers aiming to innovate in peptide-based therapeutics.

Synonyms
Fmoc-L-Trp(5-OMe)-OH
CAS Number
1219184-52-7, 460751-69-3
Purity
≥ 98.5% (Chiral HPLC)
Molecular Formula
C27H24N2O5
Molecular Weight
456.49
MDL Number
MFCD28166522
PubChem ID
22309442
Melting Point
158 - 160 °C (Lit.)
Appearance
Off-white powder/solid
Optical Rotation
[a]D20 = -24 ± 1 ° (C=1 in DMF)
Conditions
Store at 0 - 8 °C
General Information
Synonyms
Fmoc-L-Trp(5-OMe)-OH
CAS Number
1219184-52-7, 460751-69-3
Purity
≥ 98.5% (Chiral HPLC)
Molecular Formula
C27H24N2O5
Molecular Weight
456.49
MDL Number
MFCD28166522
PubChem ID
22309442
Melting Point
158 - 160 °C (Lit.)
Appearance
Off-white powder/solid
Optical Rotation
[a]D20 = -24 ± 1 ° (C=1 in DMF)
Conditions
Store at 0 - 8 °C
Properties
Additional property information coming soon!
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Safety and Regulations
Hazmat
No
Antibiotic
No
DEA-regulated
No
Warnings
-
Applications

Fmoc-5-methoxy-L-tryptophan is widely utilized in research focused on:

  • Peptide Synthesis: This compound serves as a key building block in solid-phase peptide synthesis, allowing researchers to create complex peptides with specific sequences for various applications.
  • Drug Development: Its unique structure makes it valuable in the development of pharmaceuticals, particularly in designing compounds that target serotonin receptors, which are crucial in treating mood disorders.
  • Biotechnology: In the field of biotechnology, it is used to modify proteins, enhancing their stability and functionality, which is essential for creating effective biotherapeutics.
  • Research in Neuroscience: The compound's analogs are often studied for their effects on neurotransmitter systems, providing insights into brain function and potential treatments for neurological conditions.
  • Fluorescent Labeling: Fmoc-5-methoxy-L-tryptophan can be utilized in fluorescent labeling techniques, aiding in the visualization of biomolecules in various biological research settings.

Citations