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Catalog Number:
38418
CAS Number:
68373-14-8
Sulbactam
Purity:
98 - 102% (Assay, on anhydrous basis)
Synonym(s):
(2S,5R)-3,3-Dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid 4,4-dioxide, Betamaze
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Product Information

Sulbactam is a potent β-lactamase inhibitor that plays a crucial role in enhancing the efficacy of β-lactam antibiotics against resistant bacterial strains. This compound is particularly valuable in clinical settings, where it is often combined with antibiotics such as ampicillin to combat infections caused by β-lactamase-producing bacteria. Sulbactam's unique structure allows it to effectively inhibit the enzymes that would otherwise degrade these antibiotics, thereby restoring their antibacterial activity. This makes it an essential component in the treatment of various infections, including those caused by Escherichia coli and Klebsiella pneumoniae, which are known for their resistance to standard treatments.

In addition to its clinical applications, Sulbactam is also being explored in research settings for its potential to enhance the effectiveness of other antimicrobial agents. Its ability to synergistically improve antibiotic performance makes it a valuable asset in the ongoing battle against antibiotic resistance. Researchers and healthcare professionals can leverage Sulbactam to develop more effective treatment regimens, ultimately improving patient outcomes and expanding the arsenal against resistant pathogens.

Synonyms
(2S,5R)-3,3-Dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid 4,4-dioxide, Betamaze
CAS Number
68373-14-8
Purity
98 - 102% (Assay, on anhydrous basis)
Molecular Formula
C8H11NO5S
Molecular Weight
233.24
MDL Number
MFCD00867005
PubChem ID
5316
Appearance
White to almost white crystalline powder
Optical Rotation
[a]20D = 242 - 256 º
Conditions
Store at 0-8 °C
General Information
Synonyms
(2S,5R)-3,3-Dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid 4,4-dioxide, Betamaze
CAS Number
68373-14-8
Purity
98 - 102% (Assay, on anhydrous basis)
Molecular Formula
C8H11NO5S
Molecular Weight
233.24
MDL Number
MFCD00867005
PubChem ID
5316
Appearance
White to almost white crystalline powder
Optical Rotation
[a]20D = 242 - 256 º
Conditions
Store at 0-8 °C
Properties
Additional property information coming soon!
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Safety and Regulations
Hazmat
No
Antibiotic
No
DEA-regulated
No
Warnings
-
Applications

Sulbactam is widely utilized in research focused on:

  • Antibiotic Development: Sulbactam is primarily used as a beta-lactamase inhibitor, enhancing the efficacy of penicillin antibiotics against resistant bacterial strains. This application is crucial in the pharmaceutical industry for developing new treatments for infections.
  • Combination Therapy: It is often combined with other antibiotics, such as ampicillin, to treat various infections, including those caused by Escherichia coli and Klebsiella pneumoniae. This synergy helps in overcoming bacterial resistance.
  • Veterinary Medicine: Sulbactam is also applied in veterinary medicine to treat infections in animals, ensuring better health outcomes and reducing the risk of antibiotic resistance in veterinary practices.
  • Research on Antibiotic Resistance: Researchers use sulbactam to study mechanisms of antibiotic resistance, providing valuable insights that can lead to the development of more effective antimicrobial agents.
  • Formulation Development: The compound is utilized in the formulation of injectable and oral medications, allowing for flexible dosing options and improved patient compliance in treating bacterial infections.

Citations