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Catalog Number:
38463
CAS Number:
1257852-79-1
Fmoc-5-fluoro-D-tryptophan
Purity:
≥ 99.5% (Chiral HPLC)
Synonym(s):
Fmoc-D-Trp(5-F)-OH
Documents
$80.00 /100MG
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Product Information

Fmoc-5-fluoro-D-tryptophan is a valuable amino acid derivative widely utilized in peptide synthesis and drug development. This compound features a fluorenylmethoxycarbonyl (Fmoc) protecting group, which is essential for the selective protection of the amino group during the synthesis of peptides. The incorporation of a fluorine atom at the 5-position of the indole ring enhances its biological activity and stability, making it an attractive candidate for researchers focusing on medicinal chemistry and biochemistry.

This compound is particularly beneficial in the design of peptide-based therapeutics, where the unique properties of fluorinated amino acids can improve the pharmacokinetic profiles of peptides. Its application extends to the development of novel pharmaceuticals, where it can serve as a building block for creating bioactive peptides with enhanced potency and selectivity. Researchers in the fields of drug discovery and peptide synthesis will find Fmoc-5-fluoro-D-tryptophan to be an essential tool in their arsenal, facilitating the creation of innovative therapeutic agents.

Synonyms
Fmoc-D-Trp(5-F)-OH
CAS Number
1257852-79-1
Purity
≥ 99.5% (Chiral HPLC)
Molecular Formula
C26H21FN2O4
Molecular Weight
444.45
MDL Number
MFCD16883069
PubChem ID
22309438
Melting Point
168 - 183 °C
Appearance
White to off-white powder
Optical Rotation
[a]D20 = + 20 ± 2 ° (C = 1 in DMF)
Conditions
Store at 0 - 8 °C
General Information
Synonyms
Fmoc-D-Trp(5-F)-OH
CAS Number
1257852-79-1
Purity
≥ 99.5% (Chiral HPLC)
Molecular Formula
C26H21FN2O4
Molecular Weight
444.45
MDL Number
MFCD16883069
PubChem ID
22309438
Melting Point
168 - 183 °C
Appearance
White to off-white powder
Optical Rotation
[a]D20 = + 20 ± 2 ° (C = 1 in DMF)
Conditions
Store at 0 - 8 °C
Properties
Additional property information coming soon!
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Safety and Regulations
Hazmat
No
Antibiotic
No
DEA-regulated
No
Warnings
-
Applications

Fmoc-5-fluoro-D-tryptophan is widely utilized in research focused on:

  • Peptide Synthesis: This compound serves as a key building block in the synthesis of peptides, particularly in solid-phase peptide synthesis (SPPS), allowing researchers to create complex peptides with specific functionalities.
  • Drug Development: Its unique fluorinated structure can enhance the pharmacological properties of peptide-based drugs, making it valuable in the pharmaceutical industry for developing new therapeutic agents.
  • Bioconjugation: The Fmoc protecting group enables selective reactions in bioconjugation processes, which are essential for creating targeted drug delivery systems and diagnostic tools.
  • Research in Neuroscience: As a derivative of tryptophan, it is used in studies related to neurotransmitter synthesis and can help in understanding mood regulation and mental health disorders.
  • Fluorescent Labeling: The fluorine atom can be utilized in labeling techniques, enhancing the detection and imaging of peptides in biological research, thus providing clearer insights into cellular processes.

Citations