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Acetyl-L-leucine methyl ester
Acetyl-L-leucine methyl ester is a protected amino acid derivative useful as a model substrate, building block, and analytical standard in peptide and amino acid research workflows.
- Protected amino acid building block The N-acetyl and methyl ester functionalities allow its use as a selectively activatable unit in peptide-related synthetic sequences and optimization studies.
- Chromatographic method development Its well-defined polarity and protected functional groups make it a suitable test analyte for developing and calibrating HPLC or LC-based methods for amino acid derivatives.
- Enzymatic specificity studies The acetamide and methyl ester groups enable investigation of enzyme preferences toward N-acylated and esterified leucine substrates in hydrolysis or acyl-transfer assays.
- Structure–activity relationship (SAR) models As an N-acetylated, esterified L-leucine analogue, it can serve in SAR studies probing the impact of backbone protection on recognition by biomolecular targets in vitro.
- Derivatization and deprotection optimization The compound is suitable for testing conditions and reagents for selective cleavage or transformation of acyl and ester protecting groups in method development.
- Reference compound for chiral analysis Its defined 2S stereochemistry makes it useful as a reference material when evaluating chiral separation or stereoselective reaction conditions involving leucine derivatives.
General Information
Properties
Safety and Regulations
Applications
Acetyl-L-leucine methyl ester is a protected amino acid derivative useful as a model substrate, building block, and analytical standard in peptide and amino acid research workflows.
- Protected amino acid building block The N-acetyl and methyl ester functionalities allow its use as a selectively activatable unit in peptide-related synthetic sequences and optimization studies.
- Chromatographic method development Its well-defined polarity and protected functional groups make it a suitable test analyte for developing and calibrating HPLC or LC-based methods for amino acid derivatives.
- Enzymatic specificity studies The acetamide and methyl ester groups enable investigation of enzyme preferences toward N-acylated and esterified leucine substrates in hydrolysis or acyl-transfer assays.
- Structure–activity relationship (SAR) models As an N-acetylated, esterified L-leucine analogue, it can serve in SAR studies probing the impact of backbone protection on recognition by biomolecular targets in vitro.
- Derivatization and deprotection optimization The compound is suitable for testing conditions and reagents for selective cleavage or transformation of acyl and ester protecting groups in method development.
- Reference compound for chiral analysis Its defined 2S stereochemistry makes it useful as a reference material when evaluating chiral separation or stereoselective reaction conditions involving leucine derivatives.
Documents
Safety Data Sheets (SDS)
The SDS provides comprehensive safety information on handling, storage, and disposal of the product.
Product Specification (PS)
The PS provides a comprehensive breakdown of the product’s properties, including chemical composition, physical state, purity, and storage requirements. It also details acceptable quality ranges and the product's intended applications.
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
*Catalog Number
*Lot Number
Certificates Of Origin (COO)
This COO confirms the country where the product was manufactured, and also details the materials and components used in it and whether it is derived from natural, synthetic, or other specific sources. This certificate may be required for customs, trade, and regulatory compliance.
*Catalog Number
*Lot Number
Safety Data Sheets (SDS)
The SDS provides comprehensive safety information on handling, storage, and disposal of the product.
DownloadProduct Specification (PS)
The PS provides a comprehensive breakdown of the product’s properties, including chemical composition, physical state, purity, and storage requirements. It also details acceptable quality ranges and the product's intended applications.
DownloadCertificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
*Catalog Number
*Lot Number
Certificates Of Origin (COO)
This COO confirms the country where the product was manufactured, and also details the materials and components used in it and whether it is derived from natural, synthetic, or other specific sources. This certificate may be required for customs, trade, and regulatory compliance.