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Catalog Number:
37716
CAS Number:
4291-63-8
Cladribine
Purity:
≥ 98% (HPLC)
Synonym(s):
2-Chloro-2'-dA, CdA
Documents
$526.49 /50MG
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Product Information

Cladribine is a potent nucleoside analog with significant applications in the treatment of various hematological malignancies, particularly in multiple sclerosis and certain types of leukemia. This compound functions by interfering with DNA synthesis, making it an effective therapeutic agent in oncology and immunology. Its unique structure allows for selective targeting of rapidly dividing cells, which is crucial in cancer treatment. Cladribine has been recognized for its ability to induce lymphocyte depletion, providing a strategic advantage in managing autoimmune diseases.

In addition to its therapeutic uses, Cladribine is also valuable in research settings, particularly in studies focused on cellular mechanisms and drug resistance. Its effectiveness in reducing relapse rates in multiple sclerosis patients highlights its potential in chronic disease management. Researchers and healthcare professionals appreciate Cladribine for its favorable pharmacokinetic profile and the convenience of administration, which can enhance patient compliance. Overall, Cladribine stands out as a versatile compound with significant implications in both clinical and research environments.

Synonyms
2-Chloro-2'-dA, CdA
CAS Number
4291-63-8
Purity
≥ 98% (HPLC)
Molecular Formula
C10H12ClN5O3
Molecular Weight
285.69
MDL Number
MFCD00153939
PubChem ID
1546
Melting Point
219 - 221 °C
Appearance
White to almost white powder to crystal
Conditions
Store at 2 - 8 °C
General Information
Synonyms
2-Chloro-2'-dA, CdA
CAS Number
4291-63-8
Purity
≥ 98% (HPLC)
Molecular Formula
C10H12ClN5O3
Molecular Weight
285.69
MDL Number
MFCD00153939
PubChem ID
1546
Melting Point
219 - 221 °C
Appearance
White to almost white powder to crystal
Conditions
Store at 2 - 8 °C
Properties
Additional property information coming soon!
-
Safety and Regulations
Hazmat
No
Antibiotic
No
DEA-regulated
No
Warnings
-
Applications

Cladribine is widely utilized in research focused on

  • Multiple Sclerosis Treatment: Cladribine is primarily used as a therapeutic agent for treating relapsing forms of multiple sclerosis (MS). It helps reduce the frequency of MS relapses and slows disability progression, providing significant benefits for patients.
  • Leukemia Therapy: This compound is also effective in treating certain types of leukemia, particularly hairy cell leukemia. Its ability to target and eliminate malignant cells makes it a crucial option in oncology.
  • Immunosuppressive Applications: Cladribine is utilized in organ transplantation protocols to suppress the immune response, helping to prevent organ rejection. This application is vital for improving transplant success rates.
  • Research in Autoimmune Disorders: Researchers are exploring Cladribine's potential in other autoimmune diseases, such as lupus and rheumatoid arthritis, due to its immunomodulatory effects, which may offer new treatment avenues.
  • Pharmaceutical Development: The compound serves as a model for developing new drugs that target similar pathways in cell proliferation and immune response, aiding in the advancement of pharmaceutical research.

Citations