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Catalog Number:
05747
CAS Number:
201026-08-6
Ester de N -hydroxysuccinimide de Fmoc-L-norleucine
Purity:
≥ 98 % (HPLC)
Synonym(s):
Fmoc-L-Nle-OSu, Ester N- hydroxysuccinimide de l'acide Fmoc-L-2-aminohexanoïque
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Product Information

Fmoc-L-norleucine N-hydroxysuccinimide ester is a versatile compound widely utilized in peptide synthesis and drug development. This derivative of norleucine features a protective Fmoc group, which facilitates the selective coupling of amino acids during solid-phase peptide synthesis. Its unique structure allows for efficient conjugation reactions, making it an ideal choice for researchers looking to create complex peptides with high purity and yield. The N-hydroxysuccinimide ester functionality enhances its reactivity, enabling the formation of stable amide bonds with various nucleophiles, which is particularly beneficial in bioconjugation applications.

This compound is especially relevant in the fields of medicinal chemistry and biotechnology, where it can be employed to develop peptide-based therapeutics and diagnostic agents. Its ability to streamline the synthesis process while maintaining the integrity of the peptide chain makes it a preferred choice among professionals. Additionally, Fmoc-L-norleucine N-hydroxysuccinimide ester offers advantages over similar compounds by providing improved solubility and stability, thereby enhancing overall reaction efficiency.

Synonyms
Fmoc-L-Nle-OSu, Ester N- hydroxysuccinimide de l'acide Fmoc-L-2-aminohexanoïque
CAS Number
201026-08-6
Purity
≥ 98 % (HPLC)
Molecular Formula
C25H26N2O6
Molecular Weight
450.5
MDL Number
MFCD00237394
PubChem ID
137706054
Melting Point
104-111 °C
Appearance
Poudre blanche
Optical Rotation
[a] D 20 = -29 ± 2º (C = 1 dans DMF)
Conditions
Conserver à 0-8°C
General Information
Synonyms
Fmoc-L-Nle-OSu, Ester N- hydroxysuccinimide de l'acide Fmoc-L-2-aminohexanoïque
CAS Number
201026-08-6
Purity
≥ 98 % (HPLC)
Molecular Formula
C25H26N2O6
Molecular Weight
450.5
MDL Number
MFCD00237394
PubChem ID
137706054
Melting Point
104-111 °C
Appearance
Poudre blanche
Optical Rotation
[a] D 20 = -29 ± 2º (C = 1 dans DMF)
Conditions
Conserver à 0-8°C
Properties
Additional property information coming soon!
-
Safety and Regulations
Hazmat
Non
Antibiotic
Non
DEA-regulated
Non
Warnings
-
Applications

Fmoc-L-norleucine N-hydroxysuccinimide ester is widely utilized in research focused on:

  • Peptide Synthesis: This compound serves as a key building block in the synthesis of peptides, allowing researchers to create complex structures efficiently. Its protective Fmoc group enables selective deprotection, facilitating the stepwise assembly of peptides.
  • Drug Development: In pharmaceutical research, it is used to develop peptide-based drugs, particularly in targeting specific biological pathways. Its stability and reactivity make it an excellent candidate for creating therapeutic agents.
  • Bioconjugation: The N-hydroxysuccinimide (NHS) moiety allows for efficient coupling to amine-containing molecules, making it valuable in creating bioconjugates for diagnostics and targeted drug delivery systems.
  • Protein Engineering: This compound is utilized in modifying proteins to enhance their properties, such as stability and solubility, which is crucial in developing effective biopharmaceuticals.
  • Research in Cancer Therapeutics: Its application in creating targeted therapies for cancer treatment highlights its importance in developing innovative solutions to combat complex diseases.

Citations