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Catalog Number:
00079
CAS Number:
8068-28-8
Colistin methanesulfonate sodium salt
Grade:
meets USP specifications
Purity:
≥ 390 µg/mg (Potency, anhydrous basis)
Synonym(s):
Polymyxin E sodium methanesulfonate, Colimycin sodium methanesulfonate, (Methanesulfonic acid derivative of polymyxin E) sodium salt
Antibiotic
Documents
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Product Information

Colistin methanesulfonate sodium salt is a highly effective antibiotic used primarily in the treatment of multidrug-resistant Gram-negative bacterial infections. This compound is particularly valuable in veterinary medicine, where it is utilized to combat infections in livestock, thereby enhancing animal health and productivity. Its unique mechanism of action disrupts bacterial cell membrane integrity, making it a crucial tool in the fight against resistant strains of bacteria.

In addition to its applications in veterinary medicine, colistin methanesulfonate sodium salt is also being explored in human medicine, especially for patients with limited treatment options due to antibiotic resistance. Researchers are investigating its potential in combination therapies to enhance efficacy and reduce toxicity. The compound's stability and solubility make it suitable for various formulations, including injectable solutions. With its proven track record and ongoing research, colistin methanesulfonate sodium salt remains a significant asset in both clinical and agricultural settings.

Synonyms
Polymyxin E sodium methanesulfonate, Colimycin sodium methanesulfonate, (Methanesulfonic acid derivative of polymyxin E) sodium salt
CAS Number
8068-28-8
Purity
≥ 390 µg/mg (Potency, anhydrous basis)
Grade
meets USP specifications
Molecular Formula
C58H115N16Na5O28S5
Molecular Weight
1759.9
MDL Number
MFCD31707668
PubChem ID
216258
Appearance
White powder
Conditions
Store at 0-8 °C
General Information
Synonyms
Polymyxin E sodium methanesulfonate, Colimycin sodium methanesulfonate, (Methanesulfonic acid derivative of polymyxin E) sodium salt
CAS Number
8068-28-8
Purity
≥ 390 µg/mg (Potency, anhydrous basis)
Grade
meets USP specifications
Molecular Formula
C58H115N16Na5O28S5
Molecular Weight
1759.9
MDL Number
MFCD31707668
PubChem ID
216258
Appearance
White powder
Conditions
Store at 0-8 °C
Properties
Additional property information coming soon!
-
Safety and Regulations
Hazmat
No
Antibiotic
Yes
DEA-regulated
No
Warnings
-
Applications

Colistin methanesulfonate sodium salt is widely utilized in research focused on:

  • Antibiotic Therapy: This compound is primarily used as an antibiotic to treat infections caused by multidrug-resistant Gram-negative bacteria, particularly in clinical settings where other antibiotics are ineffective.
  • Veterinary Medicine: It is commonly administered in veterinary practices to manage infections in livestock, helping to ensure animal health and food safety.
  • Pharmaceutical Research: Researchers use it to study the mechanisms of antibiotic resistance, providing insights that can lead to the development of new therapeutic strategies.
  • Formulation Development: In the pharmaceutical industry, it serves as a key ingredient in formulations aimed at enhancing the efficacy of existing antibiotics, particularly in combination therapies.
  • Clinical Trials: Colistin methanesulfonate sodium salt is often involved in clinical trials aimed at evaluating new treatment regimens, contributing to the advancement of medical knowledge and patient care.

Citations