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Catalog Number:
00359
CAS Number:
28380-24-7
Nigericin sodium salt (from Streptomyces hygroscopicus)
Purity:
≥ 99% (TLC)
Synonym(s):
Antibiotic K178
Hazmat
Temperature Sensitive
Antibiotic
Documents
$51.18 /5MG
Pack Size Availability Price
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Product Information

Nigericin sodium salt, derived from *Streptomyces hygroscopicus*, is a potent ionophore known for its ability to facilitate the transport of potassium ions across cellular membranes. This unique property makes it invaluable in various research applications, particularly in studies involving ion transport mechanisms and cellular signaling pathways. Researchers utilize Nigericin sodium salt in pharmacological studies to explore its effects on cellular metabolism and its potential therapeutic applications in conditions such as hypertension and heart disease.

Moreover, Nigericin sodium salt is recognized for its role in enhancing the efficacy of certain antibiotics by disrupting the ionic balance within bacterial cells, thereby increasing their susceptibility to treatment. Its ability to modulate ion concentrations also makes it a useful tool in neurobiology, where it aids in understanding neurotransmitter release and neuronal excitability. With its diverse applications, Nigericin sodium salt stands out as a critical compound for researchers and industry professionals focused on advancing scientific knowledge and therapeutic strategies.

Synonyms
Antibiotic K178
CAS Number
28380-24-7
Purity
≥ 99% (TLC)
Molecular Formula
C40H67O11Na
Molecular Weight
747.0
MDL Number
MFCD30377206
PubChem ID
4490
Melting Point
266-271 °C
Appearance
White powder
Conditions
Store at ≤ -4 °C
General Information
Synonyms
Antibiotic K178
CAS Number
28380-24-7
Purity
≥ 99% (TLC)
Molecular Formula
C40H67O11Na
Molecular Weight
747.0
MDL Number
MFCD30377206
PubChem ID
4490
Melting Point
266-271 °C
Appearance
White powder
Conditions
Store at ≤ -4 °C
Properties
Additional property information coming soon!
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Safety and Regulations
Hazmat
Yes
Antibiotic
Yes
DEA-regulated
No
Warnings
-
Applications

Nigericin sodium salt (from Streptomyces hygroscopicus) is widely utilized in research focused on:

  • Cell Biology: This compound is often used as a potassium ionophore, facilitating the study of ion transport mechanisms across cell membranes. Researchers can investigate cellular responses to changes in ion concentrations, which is crucial for understanding various physiological processes.
  • Pharmacology: Nigericin sodium salt is valuable in drug development, particularly in evaluating the effects of ionophores on drug delivery systems. Its ability to alter membrane permeability can enhance the efficacy of certain therapeutic agents.
  • Microbiology: In microbiological studies, this compound aids in the examination of microbial metabolism and growth conditions. It can be used to manipulate ion concentrations in culture media, providing insights into microbial behavior under different environmental stresses.
  • Neuroscience: The compound is utilized in neurophysiological research to study the role of potassium ions in neuronal excitability and signaling. This application helps in understanding neurological disorders and developing potential treatments.
  • Biochemistry: Nigericin sodium salt is employed in enzyme assays and biochemical pathways analysis, allowing researchers to explore enzyme kinetics and the impact of ion transport on metabolic processes.

Citations