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Catalog Number:
02573
CAS Number:
41153-30-4
Boc-4-fluoro-L-phenylalanine
Purity:
≥ 99% (HPLC)
Synonym(s):
Boc-L-Phe(4-F)-OH, Boc-p-fluoro-L-Phe-OH, Boc-Phe(4-F)-OH
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Product Information

Boc-4-fluoro-L-phenylalanine is a valuable amino acid derivative widely utilized in peptide synthesis and medicinal chemistry. This compound features a Boc (tert-butyloxycarbonyl) protecting group, which enhances its stability and solubility, making it an ideal choice for researchers focusing on the development of novel peptides and pharmaceuticals. Its unique 4-fluorophenyl substitution allows for the introduction of fluorine, a feature that can significantly influence the biological activity and pharmacokinetics of the resulting peptides.

In practical applications, Boc-4-fluoro-L-phenylalanine is employed in the synthesis of bioactive peptides, particularly those targeting specific receptors in drug discovery processes. Its ability to modify peptide properties while maintaining compatibility with standard coupling reactions makes it a preferred choice among chemists. Additionally, the compound's stability under various reaction conditions ensures reliable outcomes in complex synthetic pathways, providing researchers with a robust tool for advancing their projects.

Synonyms
Boc-L-Phe(4-F)-OH, Boc-p-fluoro-L-Phe-OH, Boc-Phe(4-F)-OH
CAS Number
41153-30-4
Purity
≥ 99% (HPLC)
Molecular Formula
C14H18FNO4
Molecular Weight
283.2
MDL Number
MFCD00079672
PubChem ID
7020909
Melting Point
78-84 °C
Appearance
White to off-white solid
Optical Rotation
[a]D20 = +27 ± 2º (C=1 in EtOAc)
Conditions
Store at 0-8 °C
General Information
Synonyms
Boc-L-Phe(4-F)-OH, Boc-p-fluoro-L-Phe-OH, Boc-Phe(4-F)-OH
CAS Number
41153-30-4
Purity
≥ 99% (HPLC)
Molecular Formula
C14H18FNO4
Molecular Weight
283.2
MDL Number
MFCD00079672
PubChem ID
7020909
Melting Point
78-84 °C
Appearance
White to off-white solid
Optical Rotation
[a]D20 = +27 ± 2º (C=1 in EtOAc)
Conditions
Store at 0-8 °C
Properties
Additional property information coming soon!
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Safety and Regulations
Hazmat
No
Antibiotic
No
DEA-regulated
No
Warnings
-
Applications

Boc-4-fluoro-L-phenylalanine is widely utilized in research focused on

  • Peptide Synthesis: This compound serves as a key building block in the synthesis of peptides, allowing researchers to create modified proteins with enhanced properties for drug development.
  • Drug Discovery: Its unique fluorine substitution can improve the pharmacokinetic properties of pharmaceutical candidates, making it valuable in the design of new therapeutics.
  • Bioconjugation: The reactive functional groups in Boc-4-fluoro-L-phenylalanine facilitate bioconjugation processes, enabling the attachment of drugs to antibodies for targeted therapies.
  • Research in Neuroscience: This compound is used in studies investigating neurotransmitter receptors, helping to explore the role of modified amino acids in brain function and disorders.
  • Protein Engineering: It is applied in the engineering of proteins to study structure-function relationships, providing insights into enzyme activity and stability.

Citations