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Catalog Number:
02702
CAS Number:
111662-64-7
Fmoc-γ-carboxy γ-(di-tert-butyl ester)-L-glutamic acid
Purity:
≥ 99% (HPLC)
Synonym(s):
Fmoc-γ-carboxy-γ-(di-tert-butyl ester)-L-glutamic acid, Fmoc-γ-carboxy-L-Glu(OtBu)2-OH
Temperature Sensitive
Documents
$68.90 /25MG
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Product Information

Fmoc-g-carboxy g-(di-tert-butyl ester)-L-glutamic acid is a versatile compound widely utilized in peptide synthesis and drug development. This protected form of glutamic acid features a fluorenylmethoxycarbonyl (Fmoc) group, which is essential for the selective protection of amino acids during solid-phase peptide synthesis. Its di-tert-butyl ester groups enhance solubility and stability, making it particularly useful in organic synthesis and biochemistry applications. Researchers appreciate its ability to facilitate the formation of complex peptides while minimizing side reactions, thus ensuring high yields and purity.

This compound is especially relevant in the pharmaceutical industry, where it can be employed in the design of peptide-based therapeutics. Its unique structure allows for the incorporation of glutamic acid into peptides, which can be critical for biological activity and interaction with target proteins. Additionally, its stability under various reaction conditions makes it an ideal choice for researchers looking to streamline their synthesis processes. With its proven track record in peptide chemistry, Fmoc-g-carboxy g-(di-tert-butyl ester)-L-glutamic acid stands out as a valuable tool for advancing research and development in medicinal chemistry.

Synonyms
Fmoc-γ-carboxy-γ-(di-tert-butyl ester)-L-glutamic acid, Fmoc-γ-carboxy-L-Glu(OtBu)2-OH
CAS Number
111662-64-7
Purity
≥ 99% (HPLC)
Molecular Formula
C29H35NO8
Molecular Weight
525.6
MDL Number
MFCD00038770
PubChem ID
5043441
Melting Point
123-129 ºC (crystals from ethyl acetate/hexanes)
Appearance
White crystalline powder
Optical Rotation
[a]D = -7.0 ± 2º (C=1 in MeOH)
Conditions
Store at ≤ -4 °C
General Information
Synonyms
Fmoc-γ-carboxy-γ-(di-tert-butyl ester)-L-glutamic acid, Fmoc-γ-carboxy-L-Glu(OtBu)2-OH
CAS Number
111662-64-7
Purity
≥ 99% (HPLC)
Molecular Formula
C29H35NO8
Molecular Weight
525.6
MDL Number
MFCD00038770
PubChem ID
5043441
Melting Point
123-129 ºC (crystals from ethyl acetate/hexanes)
Appearance
White crystalline powder
Optical Rotation
[a]D = -7.0 ± 2º (C=1 in MeOH)
Conditions
Store at ≤ -4 °C
Properties
Additional property information coming soon!
-
Safety and Regulations
Hazmat
No
Antibiotic
No
DEA-regulated
No
Warnings
-
Applications

Fmoc-g-carboxy g-(di-tert-butyl ester)-L-glutamic acid is widely utilized in research focused on:

  • Peptide Synthesis: This compound serves as a key building block in the synthesis of peptides, allowing researchers to create complex proteins with specific functionalities. Its protective groups facilitate selective reactions, enhancing the efficiency of the synthesis process.
  • Drug Development: In pharmaceutical research, it is used to design and optimize peptide-based drugs. The ability to modify the structure easily helps in tailoring compounds for better efficacy and reduced side effects.
  • Bioconjugation: This chemical is valuable in bioconjugation techniques, where it aids in attaching biomolecules to surfaces or other molecules, improving drug delivery systems and diagnostic tools.
  • Research in Neuroscience: It plays a role in studying neurotransmitter systems by enabling the synthesis of glutamate analogs, which are crucial for understanding synaptic transmission and potential therapeutic targets.
  • Material Science: The compound is also explored in the development of smart materials, where its unique properties can be harnessed to create responsive systems for various applications, including sensors and drug delivery vehicles.

Citations