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Catalog Number:
03777
CAS Number:
13726-69-7
Boc-L-trans-4-hydroxyproline
Purity:
≥ 99% (Assay)
Synonym(s):
Boc-L-Hyp-OH, Boc-(2S,4R-4-hydroxypyrrolidine-2-carboxylic acid
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Product Information

Boc-L-trans-4-hydroxyproline is a valuable amino acid derivative widely utilized in peptide synthesis and pharmaceutical research. This compound features a tert-butoxycarbonyl (Boc) protecting group, which enhances its stability and solubility, making it an ideal choice for various applications in organic synthesis. Its unique structure allows for the incorporation of hydroxyl groups into peptides, which can significantly influence the biological activity and stability of the resulting compounds. Researchers often employ Boc-L-trans-4-hydroxyproline in the development of bioactive peptides, particularly in the fields of drug discovery and development, where modifications to peptide structure can lead to improved therapeutic profiles.

In addition to its role in peptide synthesis, Boc-L-trans-4-hydroxyproline is also explored for its potential applications in the development of collagen mimetics and other biomaterials. Its ability to mimic natural amino acid sequences makes it a promising candidate for creating materials that can interact favorably with biological systems. This compound's versatility and relevance in both academic and industrial settings make it an essential tool for researchers aiming to innovate in the fields of biochemistry and materials science.

Synonyms
Boc-L-Hyp-OH, Boc-(2S,4R-4-hydroxypyrrolidine-2-carboxylic acid
CAS Number
13726-69-7
Purity
≥ 99% (Assay)
Molecular Formula
C10H17NO5
Molecular Weight
231.3
MDL Number
MFCD00053370
PubChem ID
335255
Melting Point
119-125 °C
Appearance
White to off-white powder
Optical Rotation
[a]D = -51 to -55º (C=1 in DMF)
Conditions
Store at 0-8°C
General Information
Synonyms
Boc-L-Hyp-OH, Boc-(2S,4R-4-hydroxypyrrolidine-2-carboxylic acid
CAS Number
13726-69-7
Purity
≥ 99% (Assay)
Molecular Formula
C10H17NO5
Molecular Weight
231.3
MDL Number
MFCD00053370
PubChem ID
335255
Melting Point
119-125 °C
Appearance
White to off-white powder
Optical Rotation
[a]D = -51 to -55º (C=1 in DMF)
Conditions
Store at 0-8°C
Properties
Additional property information coming soon!
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Safety and Regulations
Hazmat
No
Antibiotic
No
DEA-regulated
No
Warnings
-
Applications

Boc-L-trans-4-hydroxyproline is widely utilized in research focused on:

  • Peptide Synthesis: This compound serves as a key building block in the synthesis of peptides, particularly in the development of bioactive peptides that can be used in pharmaceuticals.
  • Drug Development: Its unique structure allows for the modification of drug candidates, enhancing their stability and bioavailability, which is crucial in medicinal chemistry.
  • Biomaterials: The compound is used in creating hydrogels and other biomaterials, which are essential in tissue engineering and regenerative medicine.
  • Research on Collagen: It plays a significant role in studying collagen stability and structure, providing insights into skin health and wound healing.
  • Cosmetic Formulations: Its properties make it beneficial in cosmetic products aimed at improving skin texture and hydration, appealing to the beauty and personal care industry.

Citations