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Catalog Number:
12553
CAS Number:
137348-86-8
Di-tert-butyl-N,N-diisopropylphosphoramidite
Purity:
≥ 97% (GC)
Documents
$23.54 /1G
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Product Information

Di-tert-butyl-N,N-diisopropylphosphoramidite is a versatile phosphoramidite compound widely utilized in the field of organic synthesis, particularly in the production of oligonucleotides. This compound serves as a crucial building block in the synthesis of DNA and RNA sequences, making it invaluable for researchers in molecular biology and genetic engineering. Its unique structure, featuring two tert-butyl groups and two isopropyl groups, enhances its stability and reactivity, allowing for efficient coupling reactions.

Researchers appreciate Di-tert-butyl-N,N-diisopropylphosphoramidite for its ability to facilitate the formation of phosphodiester bonds, which are essential for the integrity of nucleic acid structures. This compound is particularly advantageous in automated synthesizers, where its compatibility with various coupling protocols streamlines the oligonucleotide synthesis process. Additionally, its high purity and reliable performance make it a preferred choice for laboratories focused on gene synthesis, antisense oligonucleotide development, and other applications in nucleic acid research.

CAS Number
137348-86-8
Purity
≥ 97% (GC)
Molecular Formula
C14H32NO2P
Molecular Weight
277.4
MDL Number
MFCD00153506
PubChem ID
853005
Density
0.879 g/mL at 25 °C
Appearance
Clear colorless liquid
Boiling Point
85-90 °C/0.2 mmHg
Refractive Index
n 20/D 1.444
Conditions
Store at 0-8 °C
General Information
CAS Number
137348-86-8
Purity
≥ 97% (GC)
Molecular Formula
C14H32NO2P
Molecular Weight
277.4
MDL Number
MFCD00153506
PubChem ID
853005
Density
0.879 g/mL at 25 °C
Appearance
Clear colorless liquid
Boiling Point
85-90 °C/0.2 mmHg
Refractive Index
n 20/D 1.444
Conditions
Store at 0-8 °C
Properties
Additional property information coming soon!
-
Safety and Regulations
Hazmat
No
Antibiotic
No
DEA-regulated
No
Warnings
-
Applications

Di-tert-butyl-N,N-diisopropylphosphoramidite is widely utilized in research focused on:

  • DNA Synthesis: This compound serves as a key reagent in the synthesis of oligonucleotides, which are essential for genetic research, diagnostics, and therapeutic applications.
  • Phosphoramidite Chemistry: It plays a crucial role in the development of phosphoramidite chemistry, allowing for the efficient coupling of nucleotides, thus enhancing the yield and purity of synthesized DNA strands.
  • Drug Development: The compound is used in the pharmaceutical industry for the synthesis of nucleotide analogs, which can lead to the development of new antiviral and anticancer drugs.
  • Bioconjugation: It is applied in bioconjugation techniques, facilitating the attachment of biomolecules to surfaces or other molecules, which is vital in creating targeted drug delivery systems.
  • Research in Molecular Biology: Researchers leverage its properties to explore gene expression and regulation, contributing to advancements in molecular biology and biotechnology.

Citations