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Catalog Number:
15122
CAS Number:
210282-31-8
Fmoc-3-iodo-L-phenylalanine
Purity:
≥ 98% (HPLC)
Synonym(s):
Fmoc-L-Phe(3-I)-OH, Fmoc-3-iodo-L-Phe-OH, (S-2-Fmoc-2-amino-3-(3-iodophenyl)propionic acid
Documents
$95.00 /250MG
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Product Information

Fmoc-3-iodo-L-phenylalanine is a versatile amino acid derivative widely utilized in peptide synthesis and drug development. This compound features a fluorenylmethoxycarbonyl (Fmoc) protecting group, which is essential for the selective protection of amino groups during solid-phase peptide synthesis. The presence of the iodine atom enhances its reactivity, making it a valuable building block for the creation of complex peptides and biologically active compounds. Researchers and industry professionals appreciate its role in the synthesis of peptide-based therapeutics, particularly in the development of targeted cancer treatments and other pharmaceuticals.

Additionally, Fmoc-3-iodo-L-phenylalanine's unique properties allow for the introduction of iodine into peptide sequences, which can be beneficial for radiolabeling and imaging applications in medical research. Its stability and compatibility with various coupling reagents further enhance its utility in synthetic chemistry. This compound stands out for its ability to facilitate the design of novel peptide structures, making it an essential tool for researchers focused on advancing drug discovery and development.

Synonyms
Fmoc-L-Phe(3-I)-OH, Fmoc-3-iodo-L-Phe-OH, (S-2-Fmoc-2-amino-3-(3-iodophenyl)propionic acid
CAS Number
210282-31-8
Purity
≥ 98% (HPLC)
Molecular Formula
C24H20INO4
Molecular Weight
513.4
MDL Number
MFCD01632252
PubChem ID
53427493
Melting Point
135-139 °C
Appearance
Off-white powder
Optical Rotation
[a]D25 = -19 ± 2º (C=1 in DMF)
Conditions
Store at 0-8 °C
General Information
Synonyms
Fmoc-L-Phe(3-I)-OH, Fmoc-3-iodo-L-Phe-OH, (S-2-Fmoc-2-amino-3-(3-iodophenyl)propionic acid
CAS Number
210282-31-8
Purity
≥ 98% (HPLC)
Molecular Formula
C24H20INO4
Molecular Weight
513.4
MDL Number
MFCD01632252
PubChem ID
53427493
Melting Point
135-139 °C
Appearance
Off-white powder
Optical Rotation
[a]D25 = -19 ± 2º (C=1 in DMF)
Conditions
Store at 0-8 °C
Properties
Additional property information coming soon!
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Safety and Regulations
Hazmat
No
Antibiotic
No
DEA-regulated
No
Warnings
-
Applications

Fmoc-3-iodo-L-phenylalanine is widely utilized in research focused on:

  • Peptide Synthesis: This compound serves as a key building block in solid-phase peptide synthesis, allowing researchers to create complex peptides with specific sequences for various applications in biochemistry and pharmacology.
  • Drug Development: Its unique structure makes it valuable in the design of peptide-based drugs, particularly in targeting specific receptors or pathways in diseases, enhancing therapeutic efficacy.
  • Bioconjugation: The presence of the iodine atom allows for easy labeling and tracking in biological systems, making it useful in developing bioconjugates for imaging and therapeutic purposes.
  • Research in Cancer Therapy: This compound is being explored for its potential in developing targeted therapies for cancer, where the iodinated phenylalanine can be used to enhance the delivery of drugs to tumor sites.
  • Protein Engineering: It aids in the modification of proteins to study structure-function relationships, providing insights into protein interactions and stability in various biological contexts.

Citations