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Catalog Number:
15495
CAS Number:
352351-62-3
Fmoc-2,4-dichloro-L-phenylalanine
Purity:
≥ 99% (HPLC)
Synonym(s):
Fmoc-L-Phe(2,4-DiCl)-OH, Fmoc-L-Phe(2,4-Cl2)-OH
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Product Information

Fmoc-2,4-dichloro-L-phenylalanine is a versatile amino acid derivative widely utilized in peptide synthesis and drug development. This compound features a unique Fmoc (9-fluorenylmethoxycarbonyl) protecting group, which facilitates the selective modification of amino acids during solid-phase peptide synthesis (SPPS). Its structure, characterized by the presence of two chlorine atoms on the phenyl ring, enhances its reactivity and allows for the incorporation of specific functionalities in peptides, making it invaluable for researchers focused on developing novel therapeutics.

In addition to its role in synthetic chemistry, Fmoc-2,4-dichloro-L-phenylalanine is also employed in the design of bioactive peptides and as a building block in the creation of peptide-based drugs. Its unique properties enable researchers to explore various applications, including targeted drug delivery systems and the development of peptide mimetics. This compound stands out for its ability to improve the stability and efficacy of peptide formulations, making it a preferred choice for professionals in pharmaceutical and biotechnological fields.

Synonyms
Fmoc-L-Phe(2,4-DiCl)-OH, Fmoc-L-Phe(2,4-Cl2)-OH
CAS Number
352351-62-3
Purity
≥ 99% (HPLC)
Molecular Formula
C24H19Cl2NO4
Molecular Weight
456.32
MDL Number
MFCD01863048
PubChem ID
3349164
Melting Point
166-177 ºC
Appearance
White solid
Optical Rotation
[a]D = - 32 ± 2 º (C=1 in MeOH)
Conditions
Store at 0-8°C
General Information
Synonyms
Fmoc-L-Phe(2,4-DiCl)-OH, Fmoc-L-Phe(2,4-Cl2)-OH
CAS Number
352351-62-3
Purity
≥ 99% (HPLC)
Molecular Formula
C24H19Cl2NO4
Molecular Weight
456.32
MDL Number
MFCD01863048
PubChem ID
3349164
Melting Point
166-177 ºC
Appearance
White solid
Optical Rotation
[a]D = - 32 ± 2 º (C=1 in MeOH)
Conditions
Store at 0-8°C
Properties
Additional property information coming soon!
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Safety and Regulations
Hazmat
No
Antibiotic
No
DEA-regulated
No
Warnings
-
Applications

Fmoc-2,4-dichloro-L-phenylalanine is widely utilized in research focused on:

  • Peptide Synthesis: This compound serves as a protecting group in solid-phase peptide synthesis, allowing for the selective modification of amino acids without interfering with other functional groups.
  • Drug Development: It plays a crucial role in the development of peptide-based therapeutics, particularly in designing inhibitors for various biological targets, enhancing drug efficacy.
  • Bioconjugation: The compound is used in bioconjugation processes, facilitating the attachment of peptides to other biomolecules, which is essential in creating targeted drug delivery systems.
  • Research in Cancer Therapy: Researchers utilize it to create peptide analogs that can inhibit cancer cell proliferation, contributing to the development of novel anticancer agents.
  • Analytical Chemistry: It is employed in analytical methods to study protein interactions and dynamics, providing insights into molecular mechanisms in biological systems.

Citations