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Catalog Number:
16537
CAS Number:
203866-14-2
Boc-trans-4-fluoro-L-proline
Purity:
≥ 97% (HPLC)
Synonym(s):
Boc-trans-4-fluoro-L-Pro-OH, (2S,4R-Boc-4-fluoropyrrolidine-2-dicarboxylicacid
Documents
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Product Information

Boc-trans-4-fluoro-L-proline is a valuable building block in the synthesis of peptides and pharmaceuticals, particularly in the development of biologically active compounds. This compound features a unique fluorine substitution at the 4-position of the proline ring, which can enhance the stability and bioactivity of peptide chains. Its Boc (tert-butyloxycarbonyl) protecting group allows for selective deprotection, making it an ideal choice for chemists looking to create complex molecular architectures with precision.

Researchers and industry professionals utilize Boc-trans-4-fluoro-L-proline in various applications, including drug discovery and development, where it serves as a key intermediate in the synthesis of peptide-based therapeutics. Its ability to influence the conformation and properties of peptides makes it particularly useful in the design of inhibitors and modulators for various biological targets. The compound's unique characteristics, such as improved solubility and bioavailability compared to traditional proline derivatives, position it as a superior option for those aiming to enhance the efficacy of their pharmaceutical formulations.

Synonyms
Boc-trans-4-fluoro-L-Pro-OH, (2S,4R-Boc-4-fluoropyrrolidine-2-dicarboxylicacid
CAS Number
203866-14-2
Purity
≥ 97% (HPLC)
Molecular Formula
C10H16FNO4
Molecular Weight
233.24
MDL Number
MFCD06796085
PubChem ID
4712523
Melting Point
110-119 °C
Appearance
White solid
Optical Rotation
[a]D24 = -66 ± 2º (C=1 in MeOH)
Conditions
Store at 0-8 °C
General Information
Synonyms
Boc-trans-4-fluoro-L-Pro-OH, (2S,4R-Boc-4-fluoropyrrolidine-2-dicarboxylicacid
CAS Number
203866-14-2
Purity
≥ 97% (HPLC)
Molecular Formula
C10H16FNO4
Molecular Weight
233.24
MDL Number
MFCD06796085
PubChem ID
4712523
Melting Point
110-119 °C
Appearance
White solid
Optical Rotation
[a]D24 = -66 ± 2º (C=1 in MeOH)
Conditions
Store at 0-8 °C
Properties
Additional property information coming soon!
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Safety and Regulations
Hazmat
No
Antibiotic
No
DEA-regulated
No
Warnings
-
Applications

Boc-trans-4-fluoro-L-proline is widely utilized in research focused on

  • Pharmaceutical Development: This compound serves as a key building block in the synthesis of various pharmaceuticals, particularly in the development of peptide-based drugs. Its unique structure enhances the stability and bioactivity of therapeutic peptides.
  • Protein Engineering: Researchers use Boc-trans-4-fluoro-L-proline to introduce specific modifications in protein structures, allowing for the study of protein folding and function. This application is crucial in understanding diseases at a molecular level.
  • Material Science: The compound is employed in creating novel materials with tailored properties. Its ability to influence polymer characteristics makes it valuable in developing advanced materials for electronics and coatings.
  • Biotechnology: In the field of biotechnology, this chemical is used to enhance the efficacy of enzyme inhibitors. This application is particularly beneficial in designing treatments for various metabolic disorders.
  • Research in Neuroscience: Boc-trans-4-fluoro-L-proline is utilized in studies investigating neurotransmitter systems. Its role in modulating receptor activity provides insights into potential therapeutic targets for neurological diseases.

Citations