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Catalog Number:
31703
CAS Number:
864876-96-0
Fmoc-L-Ser(tBu)-O-CH2-Ph-OCH2-CH2-COOH
Purity:
≥ 99.5% (Chiral HPLC)
Documents
$72.31 /1G
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Product Information

Fmoc-L-Ser(tBu)-O-CH2-Ph-OCH2-CH2-COOH is a versatile amino acid derivative that plays a crucial role in peptide synthesis and drug development. This compound, known for its protective Fmoc group, is particularly valuable in solid-phase peptide synthesis (SPPS), allowing for the efficient assembly of complex peptides. Its unique structure, featuring a t-butyl protecting group and a phenyl ether linkage, enhances its stability and solubility, making it an ideal choice for researchers focused on synthesizing biologically active peptides and pharmaceuticals.

In addition to its application in SPPS, Fmoc-L-Ser(tBu)-O-CH2-Ph-OCH2-CH2-COOH is also utilized in the development of peptide-based therapeutics and in the study of protein interactions. Its ability to facilitate the introduction of serine residues into peptides allows for the exploration of post-translational modifications, which are critical for understanding protein function and regulation. Researchers will appreciate the compound's compatibility with various coupling reagents and its ease of deprotection, streamlining the synthesis process and enhancing overall yield.

CAS Number
864876-96-0
Purity
≥ 99.5% (Chiral HPLC)
Molecular Formula
C32H35NO8
Molecular Weight
561.63
MDL Number
MFCD08457853
PubChem ID
155892049
Appearance
Off-white powder
Optical Rotation
[a]20D = -12 ± 2 º (C=1 in DMF)
Conditions
Store at 0 - 8 °C
General Information
CAS Number
864876-96-0
Purity
≥ 99.5% (Chiral HPLC)
Molecular Formula
C32H35NO8
Molecular Weight
561.63
MDL Number
MFCD08457853
PubChem ID
155892049
Appearance
Off-white powder
Optical Rotation
[a]20D = -12 ± 2 º (C=1 in DMF)
Conditions
Store at 0 - 8 °C
Properties
Additional property information coming soon!
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Safety and Regulations
Hazmat
No
Antibiotic
No
DEA-regulated
No
Warnings
-
Applications

Fmoc-L-Ser(tBu)-O-CH2-Ph-OCH2-CH2-COOH is widely utilized in research focused on:

  • Peptide Synthesis: This compound serves as a key building block in the synthesis of peptides, allowing for the incorporation of serine residues with protective groups that enhance stability during chemical reactions.
  • Drug Development: In pharmaceutical research, it is used to create modified peptides that can improve the efficacy and bioavailability of therapeutic agents, particularly in targeting specific biological pathways.
  • Bioconjugation: The compound's reactive groups facilitate the conjugation of peptides to various biomolecules, such as antibodies or nanoparticles, which is essential for developing targeted drug delivery systems.
  • Research in Protein Engineering: It is employed in the design of novel proteins with enhanced properties, aiding researchers in creating proteins that can withstand extreme conditions or have improved functionality.
  • Diagnostics: The compound can be used in the development of diagnostic tools, where modified peptides can serve as biomarkers for disease detection, providing more accurate and sensitive testing methods.

Citations