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Catalog Number:
15380
CAS Number:
270065-78-6
Fmoc-3-trifluorométhyl-L-β-homophénylalanine
Purity:
≥ 99 % (HPLC)
Synonym(s):
Fmoc-L-β-HomoPhe(3-CF3)-OH, Acide Fmoc-( S )-3-amino-4-(3-trifluorométhylphényl)butyrique
Documents
$99.85 /25 mg
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Product Information

Fmoc-3-trifluoromethyl-L-b-homophenylalanine is a specialized amino acid derivative that plays a crucial role in peptide synthesis and drug development. This compound is particularly valued in the field of medicinal chemistry and biochemistry for its unique trifluoromethyl group, which enhances the lipophilicity and metabolic stability of peptides. The Fmoc (fluorenylmethyloxycarbonyl) protecting group allows for selective deprotection during solid-phase peptide synthesis, making it an essential tool for researchers aiming to create complex peptide structures.

This amino acid derivative is widely used in the synthesis of peptide-based therapeutics and can be instrumental in developing novel compounds with improved pharmacological properties. Its ability to modify the electronic and steric properties of peptides opens up new avenues for drug discovery, particularly in targeting specific biological pathways. Researchers and industry professionals can leverage Fmoc-3-trifluoromethyl-L-b-homophenylalanine to enhance the efficacy and specificity of their peptide-based applications, making it a valuable addition to any synthetic chemistry toolkit.

Synonyms
Fmoc-L-β-HomoPhe(3-CF3)-OH, Acide Fmoc-( S )-3-amino-4-(3-trifluorométhylphényl)butyrique
CAS Number
270065-78-6
Purity
≥ 99 % (HPLC)
Molecular Formula
C 26 H 22 F 3 NON 4
Molecular Weight
469.46
MDL Number
MFCD01861068
PubChem ID
53397967
Melting Point
149 - 155 °C
Appearance
Poudre blanche
Optical Rotation
[a] D 25 = -24 ± 2º (C = 1 dans DMF)
Conditions
Conserver à 0 - 8 °C
Safety & Regulations
Hazmat
Non
Antibiotic
Non
DEA-regulated
Non
General Information
Synonyms
Fmoc-L-β-HomoPhe(3-CF3)-OH, Acide Fmoc-( S )-3-amino-4-(3-trifluorométhylphényl)butyrique
CAS Number
270065-78-6
Purity
≥ 99 % (HPLC)
Molecular Formula
C 26 H 22 F 3 NON 4
Molecular Weight
469.46
MDL Number
MFCD01861068
PubChem ID
53397967
Melting Point
149 - 155 °C
Appearance
Poudre blanche
Optical Rotation
[a] D 25 = -24 ± 2º (C = 1 dans DMF)
Conditions
Conserver à 0 - 8 °C
Safety & Regulations
Hazmat
Non
Antibiotic
Non
DEA-regulated
Non
Properties
Additional property information coming soon!
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Applications

Fmoc-3-trifluoromethyl-L-b-homophenylalanine is widely utilized in research focused on:

  • Peptide Synthesis: This compound serves as a key building block in the synthesis of peptides, particularly in solid-phase peptide synthesis (SPPS), allowing for the creation of complex peptide sequences with high purity.
  • Drug Development: Its unique trifluoromethyl group enhances the pharmacological properties of peptides, making it valuable in the design of novel therapeutics targeting various diseases.
  • Bioconjugation: The compound can be used to create bioconjugates, linking peptides to other molecules, such as drugs or imaging agents, which is crucial in targeted drug delivery systems.
  • Research in Protein Engineering: Researchers utilize this chemical to modify proteins, enhancing their stability and activity, which is essential in developing more effective enzymes and therapeutic proteins.
  • Analytical Chemistry: It is employed in the development of analytical methods for detecting and quantifying peptides, aiding in quality control and research applications in various laboratories.

Citations