Discover the new Chem-Impex: Where innovation starts with a bond.

Catalog Number:
00045
CAS Number:
59-14-3
5-Bromo-2'-deoxyuridine
Purity:
≥ 99% (HPLC)
Synonym(s):
5-Br-dU, 5-Bromo-1-(2-deoxy-β-D-ribofuranosyl)uracil
Documents
$28.04 /1G
Pack Size Availability Price
Request Bulk Quote
Product Information

5-Bromo-2'-deoxyuridine is a halogenated nucleoside analog widely utilized in molecular biology and biochemistry. This compound is particularly valuable in the study of DNA synthesis and repair mechanisms, as it can be incorporated into DNA in place of thymidine. Researchers often use 5-Bromo-2'-deoxyuridine to label proliferating cells, enabling the tracking of cell division and the analysis of cellular processes. Its unique properties make it an essential tool in cancer research, where it helps in understanding tumor growth and the effects of various treatments on rapidly dividing cells.

In addition to its applications in cell biology, 5-Bromo-2'-deoxyuridine is also employed in the development of antiviral therapies and in the study of genetic disorders. Its ability to interfere with normal DNA replication allows scientists to explore the effects of mutations and the mechanisms of drug resistance. The compound's versatility and effectiveness in various experimental settings make it a preferred choice for researchers seeking reliable results in their studies.

Synonyms
5-Br-dU, 5-Bromo-1-(2-deoxy-β-D-ribofuranosyl)uracil
CAS Number
59-14-3
Purity
≥ 99% (HPLC)
Molecular Formula
C9H11BrN2O5
Molecular Weight
307.1
MDL Number
MFCD00006529
PubChem ID
236184
Melting Point
183 - 185 °C
Appearance
White to off-white powder
Optical Rotation
[a]20D = 30 ± 10 °
Conditions
Store at 0 - 8 °C
General Information
Synonyms
5-Br-dU, 5-Bromo-1-(2-deoxy-β-D-ribofuranosyl)uracil
CAS Number
59-14-3
Purity
≥ 99% (HPLC)
Molecular Formula
C9H11BrN2O5
Molecular Weight
307.1
MDL Number
MFCD00006529
PubChem ID
236184
Melting Point
183 - 185 °C
Appearance
White to off-white powder
Optical Rotation
[a]20D = 30 ± 10 °
Conditions
Store at 0 - 8 °C
Properties
Additional property information coming soon!
-
Safety and Regulations
Hazmat
No
Antibiotic
No
DEA-regulated
No
Warnings
-
Applications

5-Bromo-2'-deoxyuridine is widely utilized in research focused on:

  • Cell Proliferation Studies: This compound is commonly used to measure cell proliferation and growth in various cell lines, helping researchers understand cancer biology and the effects of different treatments.
  • DNA Synthesis Research: It serves as a thymidine analog in DNA synthesis studies, allowing scientists to investigate the mechanisms of DNA replication and repair.
  • Antiviral Drug Development: The compound is explored in the development of antiviral therapies, particularly for its potential effects on viral replication, making it valuable in virology research.
  • Labeling of Proliferating Cells: It is used as a labeling agent in flow cytometry and microscopy to identify and track proliferating cells in tissue samples, aiding in cancer research and regenerative medicine.
  • Gene Therapy Applications: Its role in gene therapy is being studied, particularly in the context of delivering therapeutic genes to target cells, which can enhance treatment efficacy for genetic disorders.

Citations