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Catalog Number:
00134
CAS Number:
40615-39-2
5'-O-(4,4'-dimethoxytrityl)thymidine
Purity:
≥ 98% (HPLC)
Synonym(s):
5'-O-DMT-T
Documents
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Product Information

5'-O-(4,4'-dimethoxytrityl)thymidine is a specialized nucleoside derivative that plays a crucial role in the synthesis of oligonucleotides and DNA analogs. This compound is particularly valued in molecular biology and biochemistry for its ability to protect the 5'-hydroxyl group during chemical reactions, thereby enhancing the efficiency of DNA synthesis. Its unique structure, featuring two methoxy groups, contributes to its stability and solubility, making it an ideal choice for researchers engaged in the development of therapeutic oligonucleotides and gene editing technologies.

In practical applications, 5'-O-(4,4'-dimethoxytrityl)thymidine is frequently utilized in the production of phosphoramidite building blocks, which are essential for automated DNA synthesis. This compound not only streamlines the synthesis process but also improves the yield and purity of the final products. Its compatibility with various coupling reagents and its ability to undergo selective deprotection make it a preferred choice among professionals in the field. Researchers can leverage this compound to enhance their workflows in genetic research, drug development, and synthetic biology.

Synonyms
5'-O-DMT-T
CAS Number
40615-39-2
Purity
≥ 98% (HPLC)
Molecular Formula
C31H32N2O7
Molecular Weight
544.61
MDL Number
MFCD00010113
PubChem ID
627554
Appearance
White to off-white powder
Conditions
Store at 0 - 8 °C
General Information
Synonyms
5'-O-DMT-T
CAS Number
40615-39-2
Purity
≥ 98% (HPLC)
Molecular Formula
C31H32N2O7
Molecular Weight
544.61
MDL Number
MFCD00010113
PubChem ID
627554
Appearance
White to off-white powder
Conditions
Store at 0 - 8 °C
Properties
Additional property information coming soon!
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Safety and Regulations
Hazmat
No
Antibiotic
No
DEA-regulated
No
Warnings
-
Applications

5'-O-(4,4'-dimethoxytrityl)thymidine is widely utilized in research focused on:

  • Nucleic Acid Synthesis: This compound serves as a key building block in the synthesis of oligonucleotides, which are essential for genetic research, including gene editing and PCR applications.
  • Antisense Oligonucleotide Development: It is used in the development of antisense oligonucleotides, which can inhibit gene expression and are valuable in therapeutic applications for various diseases.
  • Drug Development: The compound plays a role in the formulation of nucleotide analogs, which can be used in antiviral and anticancer drug development, providing targeted treatment options.
  • Biotechnology Research: It is utilized in the production of modified nucleotides for various biotechnological applications, enhancing the efficiency of molecular cloning and sequencing techniques.
  • Diagnostic Tools: This chemical is integral in the creation of diagnostic assays, such as those used in detecting viral infections, thereby improving patient outcomes through timely diagnosis.

Citations