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Catalog Number:
00289
CAS Number:
76-05-1
Trifluoroacetic acid
Purity:
≥ 99% (Assay)
Synonym(s):
TFA
Hazmat
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Product Information

Trifluoroacetic acid is a versatile and highly useful compound widely utilized in various chemical applications. Known for its strong acidity and unique trifluoromethyl group, this compound serves as an effective reagent in organic synthesis, particularly in the production of fluorinated compounds. Its ability to act as a solvent and catalyst makes it invaluable in peptide synthesis and the preparation of pharmaceuticals, where it aids in the purification and characterization of complex molecules. Researchers appreciate its role in enhancing reaction rates and improving yields, making it a preferred choice in laboratories focused on advanced chemical research.

In addition to its applications in organic synthesis, trifluoroacetic acid is also employed in the field of analytical chemistry, particularly in chromatography, where it is used as a mobile phase modifier. Its unique properties allow for improved separation and detection of various analytes, making it essential for quality control in the pharmaceutical and environmental industries. With its strong solvation capabilities and ability to stabilize reactive intermediates, trifluoroacetic acid stands out as a critical tool for chemists and researchers aiming to innovate and optimize their processes.

Synonyms
TFA
CAS Number
76-05-1
Purity
≥ 99% (Assay)
Molecular Formula
C2HF3O2
Molecular Weight
114.02
MDL Number
MFCD00004169
PubChem ID
6422
Melting Point
-15.4 °C (Lit.)
Density
1.489 g/mL at 20 °C
Appearance
Clear colorless liquid
Boiling Point
72.4 °C (Lit.)
Refractive Index
n20/D 1.3
Conditions
Store at RT
General Information
Synonyms
TFA
CAS Number
76-05-1
Purity
≥ 99% (Assay)
Molecular Formula
C2HF3O2
Molecular Weight
114.02
MDL Number
MFCD00004169
PubChem ID
6422
Melting Point
-15.4 °C (Lit.)
Density
1.489 g/mL at 20 °C
Appearance
Clear colorless liquid
Boiling Point
72.4 °C (Lit.)
Refractive Index
n20/D 1.3
Conditions
Store at RT
Properties
Additional property information coming soon!
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Safety and Regulations
Hazmat
Yes
Antibiotic
No
DEA-regulated
No
Warnings
-
Applications

Trifluoroacetic acid is widely utilized in research focused on:

  • Organic Synthesis: It serves as a powerful reagent in the synthesis of various organic compounds, enabling the introduction of trifluoromethyl groups which enhance the biological activity of pharmaceuticals.
  • Peptide Chemistry: This compound is commonly used in peptide synthesis, particularly in the protection and deprotection of amino acids, making it essential for developing new therapeutic peptides.
  • Analytical Chemistry: Trifluoroacetic acid is employed as a solvent and reagent in chromatography, improving the separation and analysis of complex mixtures in laboratories.
  • Environmental Studies: It is utilized in the study of environmental pollutants, aiding in the analysis of fluorinated compounds in various samples, which is crucial for assessing ecological impacts.
  • Pharmaceutical Formulations: The compound is used in the formulation of certain drugs, enhancing their stability and bioavailability, which is vital for effective medication delivery.

Citations