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Catalog Number:
00329
CAS Number:
1397-89-3
Amphotericin B
Purity:
≥ 750 mg/mg (Microbial assay on dried basis)
Synonym(s):
Fungizone, Amphotericin
Antibiotic
Documents
$41.76 /250MG
Pack Size Availability Price
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Product Information

Amphotericin B is a potent antifungal agent widely recognized for its effectiveness in treating serious fungal infections, particularly in immunocompromised patients. This polyene macrolide antibiotic is derived from the bacterium Streptomyces nodosus and is primarily used in clinical settings to combat life-threatening infections such as cryptococcal meningitis and systemic candidiasis. Its unique mechanism of action involves binding to ergosterol in fungal cell membranes, leading to increased permeability and cell death, making it a critical component in antifungal therapy.

In addition to its clinical applications, Amphotericin B is also utilized in research settings to study fungal biology and the development of resistance mechanisms. Its formulation can be adapted for various delivery methods, including liposomal preparations, which enhance its therapeutic index and reduce toxicity. Researchers and healthcare professionals value Amphotericin B not only for its efficacy but also for its versatility in addressing a range of fungal pathogens, making it an indispensable tool in both medical and scientific fields.

Synonyms
Fungizone, Amphotericin
CAS Number
1397-89-3
Purity
≥ 750 mg/mg (Microbial assay on dried basis)
Molecular Formula
C47H73NO17
Molecular Weight
924.1
MDL Number
MFCD00877763
PubChem ID
1972
Melting Point
>170 °C (Decomposes gradually)
Appearance
Yellow to orange odorless powder
Conditions
Store at 0-8 °C
General Information
Synonyms
Fungizone, Amphotericin
CAS Number
1397-89-3
Purity
≥ 750 mg/mg (Microbial assay on dried basis)
Molecular Formula
C47H73NO17
Molecular Weight
924.1
MDL Number
MFCD00877763
PubChem ID
1972
Melting Point
>170 °C (Decomposes gradually)
Appearance
Yellow to orange odorless powder
Conditions
Store at 0-8 °C
Properties
Additional property information coming soon!
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Safety and Regulations
Hazmat
No
Antibiotic
Yes
DEA-regulated
No
Warnings
-
Applications

Amphotericin B is widely utilized in research focused on

  • Antifungal Treatment: It is primarily used to treat serious fungal infections, especially in immunocompromised patients, providing a critical option where other treatments may fail.
  • Pharmaceutical Development: Researchers use it as a benchmark compound in the development of new antifungal agents, allowing for comparative studies on efficacy and safety.
  • Drug Formulation: Its unique properties are leveraged in the formulation of liposomal drugs, enhancing the delivery and reducing toxicity, which is vital for patient compliance.
  • Veterinary Medicine: Amphotericin B is also applied in veterinary practices to treat fungal infections in animals, ensuring broader applications in healthcare.
  • Research on Drug Resistance: It serves as a key compound in studies investigating antifungal resistance mechanisms, helping to inform future therapeutic strategies.

Citations