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Catalog Number:
01260
CAS Number:
2022-85-7
5-Fluorocytosine
Grade:
meets USP specifications
Purity:
98.5-101.0% (HPLC)
Synonym(s):
4-Amino-5-fluoro-2-hydroxypyrimidine
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Product Information

5-Fluorocytosine is a fluorinated pyrimidine analog of cytosine, primarily recognized for its potent antifungal properties. This compound is widely utilized in the treatment of systemic fungal infections, particularly in immunocompromised patients. Its mechanism of action involves the inhibition of fungal DNA and RNA synthesis, making it an essential agent in combination therapies for conditions such as cryptococcal meningitis and candidiasis. Researchers appreciate 5-Fluorocytosine for its ability to enhance the efficacy of other antifungal agents, providing a synergistic effect that can lead to improved patient outcomes.

In addition to its clinical applications, 5-Fluorocytosine is also employed in various laboratory settings for research purposes, particularly in studies involving nucleic acid metabolism and the development of new antifungal strategies. Its unique properties, including selective toxicity towards fungal cells and its ability to penetrate biological membranes, make it a valuable tool for both therapeutic and investigative applications. With ongoing research into its potential uses, 5-Fluorocytosine continues to hold promise in the fight against resistant fungal strains.

Synonyms
4-Amino-5-fluoro-2-hydroxypyrimidine
CAS Number
2022-85-7
Purity
98.5-101.0% (HPLC)
Grade
meets USP specifications
Molecular Formula
C4H4FN3O
Molecular Weight
129.09
MDL Number
MFCD00006035
PubChem ID
3366
Melting Point
295°C (dec)
Appearance
White or almost white crystalline powder
Conditions
Store at 0-8 °C
General Information
Synonyms
4-Amino-5-fluoro-2-hydroxypyrimidine
CAS Number
2022-85-7
Purity
98.5-101.0% (HPLC)
Grade
meets USP specifications
Molecular Formula
C4H4FN3O
Molecular Weight
129.09
MDL Number
MFCD00006035
PubChem ID
3366
Melting Point
295°C (dec)
Appearance
White or almost white crystalline powder
Conditions
Store at 0-8 °C
Properties
Additional property information coming soon!
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Safety and Regulations
Hazmat
No
Antibiotic
No
DEA-regulated
No
Warnings
-
Applications

5-Fluorocytosine is widely utilized in research focused on:

  • Antifungal Treatments: This compound is primarily used in the treatment of fungal infections, particularly in immunocompromised patients, providing an effective option against certain strains of fungi.
  • Research on Cancer: It is being studied for its potential role in cancer therapies, especially in combination with other drugs, to enhance efficacy and reduce resistance in tumor cells.
  • Genetic Studies: As a nucleotide analog, it is used in molecular biology to study DNA and RNA processes, helping researchers understand gene expression and mutation mechanisms.
  • Pharmaceutical Development: The compound serves as a crucial intermediate in synthesizing other pharmaceuticals, streamlining the development of new medications.
  • Veterinary Medicine: It is also applied in treating fungal infections in animals, ensuring better health outcomes in veterinary practices.

Citations