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Catalog Number:
01410
CAS Number:
6160-80-1
4-Methylumbelliferyl-β-D-glucuronide hydrate
Purity:
≥ 98% (HPLC)
Synonym(s):
MUG, 7-(4-Methylcoumaryl)-β-D-glucopyranosiduronic acid hydrate
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Product Information

4-Methylumbelliferyl-b-D-glucuronide hydrate is a highly valuable compound widely utilized in biochemical research and diagnostics. This substrate is particularly significant in the study of glucuronidation processes, serving as a fluorogenic marker for the activity of β-glucuronidase enzymes. Its unique structure allows for the release of a fluorescent signal upon enzymatic cleavage, making it an essential tool in various assays, including drug metabolism studies and enzyme activity assessments. Researchers appreciate its sensitivity and specificity, which facilitate the detection of enzyme activity in complex biological samples.

In addition to its applications in enzymology, 4-Methylumbelliferyl-b-D-glucuronide hydrate is also employed in histochemical staining, enabling the visualization of glucuronidase activity in tissue sections. This compound stands out due to its ease of use and the clarity of results it provides, making it a preferred choice for laboratories focused on metabolic research and clinical diagnostics. Its versatility and effectiveness in various experimental setups underscore its importance in advancing our understanding of metabolic pathways and enzyme functions.

Synonyms
MUG, 7-(4-Methylcoumaryl)-β-D-glucopyranosiduronic acid hydrate
CAS Number
6160-80-1
Purity
≥ 98% (HPLC)
Molecular Formula
C16H16O9
Molecular Weight
352.3
MDL Number
MFCD09039280
PubChem ID
3683393
Appearance
White crystalline powder
Conditions
Store at 0 - 8 °C
General Information
Synonyms
MUG, 7-(4-Methylcoumaryl)-β-D-glucopyranosiduronic acid hydrate
CAS Number
6160-80-1
Purity
≥ 98% (HPLC)
Molecular Formula
C16H16O9
Molecular Weight
352.3
MDL Number
MFCD09039280
PubChem ID
3683393
Appearance
White crystalline powder
Conditions
Store at 0 - 8 °C
Properties
Additional property information coming soon!
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Safety and Regulations
Hazmat
No
Antibiotic
No
DEA-regulated
No
Warnings
-
Applications

4-Methylumbelliferyl-b-D-glucuronide hydrate is widely utilized in research focused on:

  • Enzyme Activity Assays: This compound serves as a substrate for glucuronidase enzymes, allowing researchers to measure enzyme activity in various biological samples, which is crucial for drug metabolism studies.
  • Biochemical Research: It is commonly used in studies investigating the metabolism of drugs and xenobiotics, helping scientists understand how substances are processed in the body.
  • Fluorescent Probes: The compound exhibits fluorescence upon enzymatic cleavage, making it useful as a fluorescent probe in cellular and molecular biology applications.
  • Pharmaceutical Development: Its role in assessing drug interactions with glucuronidation pathways aids pharmaceutical companies in developing safer and more effective medications.
  • Environmental Monitoring: Researchers utilize this compound to study the biodegradation of pharmaceuticals in environmental samples, contributing to ecological safety assessments.

Citations