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Catalog Number:
01544
CAS Number:
103285-22-9
5'-O-(4,4'-dimethoxytrityl)-2'-O-methyluridine
Purity:
≥ 99% (HPLC)
Synonym(s):
DMT-2'-O-methyluridine
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Product Information

5'-O-(4,4'-dimethoxytrityl)-2'-O-methyluridine is a specialized nucleoside derivative that plays a crucial role in the synthesis of oligonucleotides and other nucleic acid-related applications. This compound is particularly valued in the field of molecular biology and biochemistry for its ability to enhance the stability and solubility of RNA and DNA constructs. Its unique structure, featuring a dimethoxytrityl protecting group, allows for efficient incorporation into various nucleic acid sequences while providing protection against degradation during synthesis.

Researchers and industry professionals utilize 5'-O-(4,4'-dimethoxytrityl)-2'-O-methyluridine in the development of therapeutic oligonucleotides, RNA interference (RNAi) applications, and in the production of modified RNA for vaccine development. Its advantageous properties, such as improved resistance to nucleases and enhanced binding affinity, make it an essential component in the design of effective RNA-based therapeutics. By choosing this compound, customers can expect reliable performance in their nucleic acid synthesis projects, leading to more successful experimental outcomes.

Synonyms
DMT-2'-O-methyluridine
CAS Number
103285-22-9
Purity
≥ 99% (HPLC)
Molecular Formula
C31H32N2O8
Molecular Weight
560.6
MDL Number
MFCD00274123
Appearance
White, off-white to faint yellow powder
Conditions
Store at 0 - 8 °C
General Information
Synonyms
DMT-2'-O-methyluridine
CAS Number
103285-22-9
Purity
≥ 99% (HPLC)
Molecular Formula
C31H32N2O8
Molecular Weight
560.6
MDL Number
MFCD00274123
Appearance
White, off-white to faint yellow powder
Conditions
Store at 0 - 8 °C
Properties
Additional property information coming soon!
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Safety and Regulations
Hazmat
No
Antibiotic
No
DEA-regulated
No
Warnings
-
Applications

5'-O-(4,4'-dimethoxytrityl)-2'-O-methyluridine is widely utilized in research focused on:

  • Nucleic Acid Synthesis: This compound serves as a key building block in the synthesis of RNA oligonucleotides, allowing researchers to create custom RNA sequences for various applications in molecular biology.
  • Drug Development: It plays a crucial role in the development of RNA-based therapeutics, such as mRNA vaccines, by facilitating the incorporation of modified nucleotides that enhance stability and efficacy.
  • Gene Expression Studies: Researchers use this compound to study gene expression and regulation, as it can be incorporated into RNA probes that help in detecting specific RNA molecules in cells.
  • Biotechnology Applications: In the field of biotechnology, it is employed in the design of RNA interference (RNAi) molecules, which are essential for silencing specific genes in research and therapeutic contexts.
  • Diagnostics: The compound is valuable in the development of diagnostic tools, such as PCR assays, where modified nucleotides improve the sensitivity and specificity of the tests.

Citations