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Catalog Number:
02341
CAS Number:
658-78-6
4-Nitrophenyl trifluoroacetate
Purity:
≥ 99% (HPLC)
Synonym(s):
Trifluoroacetic acid 4-nitrophenyl ester, Sakakibara's Reagent
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Product Information

4-Nitrophenyl trifluoroacetate is a versatile chemical compound widely utilized in organic synthesis and pharmaceutical research. This compound, known for its distinctive trifluoroacetate group, serves as an effective electrophile in various reactions, making it an essential intermediate in the synthesis of biologically active molecules. Its unique structure allows for selective reactions, which can lead to the development of novel compounds with potential therapeutic applications. Researchers often leverage its reactivity in the preparation of esters and amides, contributing to advancements in medicinal chemistry and agrochemical formulations.

In addition to its synthetic utility, 4-Nitrophenyl trifluoroacetate is recognized for its role in the development of fluorescent probes and sensors, enhancing its relevance in analytical chemistry. Its stability and ease of handling make it a preferred choice for laboratory applications. By incorporating this compound into their research, professionals can streamline their synthesis processes and explore new avenues in drug discovery and material science, thus maximizing their productivity and innovation potential.

Synonyms
Trifluoroacetic acid 4-nitrophenyl ester, Sakakibara's Reagent
CAS Number
658-78-6
Purity
≥ 99% (HPLC)
Molecular Formula
C8H4F3NO4
Molecular Weight
235.12
MDL Number
MFCD00007324
PubChem ID
69569
Melting Point
34-40 °C
Appearance
Beige crystalline
Boiling Point
120 ºC
Conditions
Store at RT
General Information
Synonyms
Trifluoroacetic acid 4-nitrophenyl ester, Sakakibara's Reagent
CAS Number
658-78-6
Purity
≥ 99% (HPLC)
Molecular Formula
C8H4F3NO4
Molecular Weight
235.12
MDL Number
MFCD00007324
PubChem ID
69569
Melting Point
34-40 °C
Appearance
Beige crystalline
Boiling Point
120 ºC
Conditions
Store at RT
Properties
Additional property information coming soon!
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Safety and Regulations
Hazmat
No
Antibiotic
No
DEA-regulated
No
Warnings
-
Applications

4-Nitrophenyl trifluoroacetate is widely utilized in research focused on:

  • Synthesis of Pharmaceuticals: This compound serves as an important intermediate in the synthesis of various pharmaceutical agents, enabling the development of new medications with enhanced efficacy.
  • Bioconjugation Techniques: It is used in bioconjugation processes to attach biomolecules to surfaces or other molecules, which is essential in creating targeted drug delivery systems.
  • Analytical Chemistry: The compound acts as a reagent in analytical methods, aiding in the detection and quantification of other chemical species, thus improving the accuracy of laboratory results.
  • Polymer Chemistry: It is employed in the modification of polymers, enhancing their properties for applications in coatings, adhesives, and other materials, leading to improved performance.
  • Environmental Studies: Researchers utilize it to investigate the degradation pathways of pollutants, contributing to environmental monitoring and remediation efforts.

Citations