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Catalog Number:
02419
CAS Number:
198543-64-5
Fmoc-D-α-tert-butylglycine
Purity:
≥ 99% (Assay)
Synonym(s):
Fmoc-D-α-tert-butyl-Gly-OH, Fmoc-D-Tle-OH, (R)-N-Fmoc-2-amino-3,3-dimethyl butanoic acid
Documents
$105.36 /250MG
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Product Information

Fmoc-D-a-tert-butylglycine is a versatile amino acid derivative widely utilized in peptide synthesis and drug development. This compound features a protective Fmoc (9-fluorenylmethoxycarbonyl) group, which allows for selective deprotection during the synthesis process, making it an essential building block for researchers in the field of medicinal chemistry. Its unique tert-butyl side chain enhances solubility and stability, facilitating the formation of complex peptide structures.

In practical applications, Fmoc-D-a-tert-butylglycine is particularly valuable in the synthesis of bioactive peptides and pharmaceuticals, where precise control over the amino acid sequence is crucial. Its ability to improve the yield and purity of synthesized peptides makes it a preferred choice among chemists. Additionally, this compound can be employed in the development of peptide-based therapeutics, providing a pathway for innovative drug design. Researchers can leverage its properties to create tailored solutions for various biomedical applications, enhancing the efficacy of their projects.

Synonyms
Fmoc-D-α-tert-butyl-Gly-OH, Fmoc-D-Tle-OH, (R)-N-Fmoc-2-amino-3,3-dimethyl butanoic acid
CAS Number
198543-64-5
Purity
≥ 99% (Assay)
Molecular Formula
C21H23NO4
Molecular Weight
353.5
MDL Number
MFCD00065650
Melting Point
126 - 140 °C (Lit.)
Appearance
White to off-white powder
Optical Rotation
[a]20D = 19 ± 2 ° (C=1 in DMF)
Conditions
Store at 0 - 8 °C
General Information
Synonyms
Fmoc-D-α-tert-butyl-Gly-OH, Fmoc-D-Tle-OH, (R)-N-Fmoc-2-amino-3,3-dimethyl butanoic acid
CAS Number
198543-64-5
Purity
≥ 99% (Assay)
Molecular Formula
C21H23NO4
Molecular Weight
353.5
MDL Number
MFCD00065650
Melting Point
126 - 140 °C (Lit.)
Appearance
White to off-white powder
Optical Rotation
[a]20D = 19 ± 2 ° (C=1 in DMF)
Conditions
Store at 0 - 8 °C
Properties
Additional property information coming soon!
-
Safety and Regulations
Hazmat
No
Antibiotic
No
DEA-regulated
No
Warnings
-
Applications

Fmoc-D-a-tert-butylglycine is widely utilized in research focused on:

  • Peptide Synthesis: This compound serves as a key building block in the synthesis of peptides, allowing for the introduction of tert-butyl groups that enhance stability and solubility.
  • Drug Development: It plays a significant role in the pharmaceutical industry, particularly in the design of drug candidates that require specific amino acid configurations for optimal activity.
  • Bioconjugation: Researchers use this chemical for bioconjugation processes, linking biomolecules to enhance their functionality and targeting capabilities in therapeutic applications.
  • Protein Engineering: In protein engineering, it aids in modifying proteins to improve their properties, such as stability and resistance to degradation, which is crucial for developing effective therapeutics.
  • Analytical Chemistry: The compound is also employed in analytical chemistry for the development of new methods to study protein interactions and dynamics, providing insights that are vital for various research fields.

Citations