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Catalog Number:
03743
CAS Number:
133180-01-5
Fmoc-O-trityl-L-threonine
Purity:
≥ 98.5% (HPLC)
Synonym(s):
Fmoc-L-Thr(Trt)-OH
Documents
$36.65 /1G
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Product Information

Fmoc-O-trityl-L-threonine is a versatile amino acid derivative widely utilized in peptide synthesis and drug development. This compound features a protective Fmoc (9-fluorenylmethyloxycarbonyl) group, which is essential for the selective protection of the amino group during the synthesis of peptides. The trityl group provides additional stability and solubility, making it an excellent choice for solid-phase peptide synthesis. Researchers appreciate its ability to facilitate the formation of complex peptides while maintaining high purity and yield.

In practical applications, Fmoc-O-trityl-L-threonine is particularly valuable in the pharmaceutical industry for the development of therapeutic peptides and proteins. Its unique structure allows for the introduction of threonine residues into peptides, which can enhance biological activity and specificity. This compound is also used in the synthesis of various bioactive molecules, making it a critical component in the toolkit of chemists and biochemists focused on innovative drug design and development.

Synonyms
Fmoc-L-Thr(Trt)-OH
CAS Number
133180-01-5
Purity
≥ 98.5% (HPLC)
Molecular Formula
C38H33NO5
Molecular Weight
583.7
MDL Number
MFCD00237034
PubChem ID
53394879
Melting Point
70 - 75 °C
Appearance
White to light brown powder
Optical Rotation
[a]D20 = -23 to -28 º (C=1 in EtOAc)
Conditions
Store at 0 - 8 °C
General Information
Synonyms
Fmoc-L-Thr(Trt)-OH
CAS Number
133180-01-5
Purity
≥ 98.5% (HPLC)
Molecular Formula
C38H33NO5
Molecular Weight
583.7
MDL Number
MFCD00237034
PubChem ID
53394879
Melting Point
70 - 75 °C
Appearance
White to light brown powder
Optical Rotation
[a]D20 = -23 to -28 º (C=1 in EtOAc)
Conditions
Store at 0 - 8 °C
Properties
Additional property information coming soon!
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Safety and Regulations
Hazmat
No
Antibiotic
No
DEA-regulated
No
Warnings
-
Applications

Fmoc-O-trityl-L-threonine is widely utilized in research focused on:

  • Peptide Synthesis: This compound serves as a protecting group in the synthesis of peptides, allowing for selective reactions without interfering with other functional groups. Its stability under various conditions makes it a preferred choice for chemists.
  • Drug Development: In pharmaceutical research, it plays a crucial role in the design of peptide-based drugs, enhancing bioavailability and stability, which are critical for therapeutic efficacy.
  • Biotechnology: Used in the production of recombinant proteins, it aids in the development of biopharmaceuticals, ensuring that proteins maintain their functional integrity during synthesis.
  • Analytical Chemistry: This compound is valuable in the development of analytical methods for characterizing peptides, providing researchers with reliable data for quality control and formulation studies.
  • Academic Research: It is frequently employed in educational settings for teaching organic synthesis techniques, helping students understand the intricacies of chemical reactions and molecular manipulation.

Citations