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Catalog Number:
04114
CAS Number:
173963-93-4
Fmoc-4-cyano-L-phenylalanine
Purity:
≥ 99% (HPLC)
Synonym(s):
Fmoc-L-Phe(4-CN)-OH, Fmoc-p-cyano-L-Phe-OH, Fmoc-Phe(4-CN)-OH
Documents
$130.00 /1G
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Product Information

Fmoc-4-cyano-L-phenylalanine is a versatile amino acid derivative widely utilized in peptide synthesis and drug development. This compound features a protective Fmoc (9-fluorenylmethoxycarbonyl) group, which allows for selective deprotection during the synthesis process, making it an essential building block for researchers in the field of medicinal chemistry. Its unique structure, characterized by the presence of a cyano group, enhances its reactivity and compatibility with various coupling reactions, facilitating the formation of complex peptides.

In addition to its role in peptide synthesis, Fmoc-4-cyano-L-phenylalanine is also valuable in the development of pharmaceutical compounds, particularly those targeting specific biological pathways. Its ability to serve as a precursor for the synthesis of bioactive peptides makes it a preferred choice among researchers aiming to create novel therapeutics. The compound's stability and ease of handling further contribute to its appeal, ensuring reliable performance in laboratory settings.

Synonyms
Fmoc-L-Phe(4-CN)-OH, Fmoc-p-cyano-L-Phe-OH, Fmoc-Phe(4-CN)-OH
CAS Number
173963-93-4
Purity
≥ 99% (HPLC)
Molecular Formula
C25H20N2O4
Molecular Weight
412.4
MDL Number
MFCD00672559
PubChem ID
4351133
Melting Point
180 - 191 °C
Appearance
White crystalline powder
Optical Rotation
[a]20D = -35 ± 10 ° (C=1 in DMF)
Conditions
Store at 0 - 8 °C
General Information
Synonyms
Fmoc-L-Phe(4-CN)-OH, Fmoc-p-cyano-L-Phe-OH, Fmoc-Phe(4-CN)-OH
CAS Number
173963-93-4
Purity
≥ 99% (HPLC)
Molecular Formula
C25H20N2O4
Molecular Weight
412.4
MDL Number
MFCD00672559
PubChem ID
4351133
Melting Point
180 - 191 °C
Appearance
White crystalline powder
Optical Rotation
[a]20D = -35 ± 10 ° (C=1 in DMF)
Conditions
Store at 0 - 8 °C
Properties
Additional property information coming soon!
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Safety and Regulations
Hazmat
No
Antibiotic
No
DEA-regulated
No
Warnings
-
Applications

Fmoc-4-cyano-L-phenylalanine is widely utilized in research focused on:

  • Peptide Synthesis: This compound serves as a key building block in the synthesis of peptides, particularly in solid-phase peptide synthesis (SPPS), allowing for the creation of complex peptide sequences efficiently.
  • Drug Development: Its unique structure aids in the design of novel pharmaceuticals, particularly in creating compounds that can interact with specific biological targets, enhancing drug efficacy.
  • Bioconjugation: The presence of the cyano group facilitates bioconjugation reactions, making it useful in linking peptides to various biomolecules for therapeutic and diagnostic applications.
  • Research in Neuroscience: This chemical is utilized in studies related to neuropeptides, helping researchers understand the role of specific peptides in neurological functions and disorders.
  • Protein Engineering: It plays a role in modifying proteins to improve their stability and activity, which is crucial for developing better enzymes and therapeutic proteins.

Citations