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Catalog Number:
04125
CAS Number:
205445-52-9
Boc-3,5-difluoro-L-phenylalanine
Purity:
≥ 99% (HPLC)
Synonym(s):
Boc-L-Phe(3,5-DiF)-OH, (S-Boc-2-amino-3-(3,5-difluorophenyl)propionic acid, Boc-Phe(3,5-DiF)-OH
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$127.79 /1G
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Product Information

Boc-3,5-difluoro-L-phenylalanine is a specialized amino acid derivative that has garnered attention in the fields of medicinal chemistry and peptide synthesis. This compound features a unique difluorophenyl group, enhancing its potential as a building block for the development of novel pharmaceuticals, particularly in the design of peptide-based drugs. Its Boc (tert-butyloxycarbonyl) protecting group allows for selective reactions, making it an ideal choice for researchers looking to synthesize complex peptides with precision.

The incorporation of fluorine atoms in the structure not only improves the compound's metabolic stability but also influences its biological activity, making it a valuable candidate in drug discovery and development. Researchers have utilized Boc-3,5-difluoro-L-phenylalanine in the synthesis of biologically active peptides, which can lead to advancements in treatments for various diseases. Its unique properties and versatility in applications make it an essential tool for professionals in pharmaceutical and biotechnological research.

Synonyms
Boc-L-Phe(3,5-DiF)-OH, (S-Boc-2-amino-3-(3,5-difluorophenyl)propionic acid, Boc-Phe(3,5-DiF)-OH
CAS Number
205445-52-9
Purity
≥ 99% (HPLC)
Molecular Formula
C14H17F2NO4
Molecular Weight
301.3
MDL Number
MFCD00797555
PubChem ID
21865921
Melting Point
109-115 °C
Appearance
White to off-white powder
Optical Rotation
[a]D25 = -31 ± 2º (C=1 in DMF)
Conditions
Store at 0-8 °C
General Information
Synonyms
Boc-L-Phe(3,5-DiF)-OH, (S-Boc-2-amino-3-(3,5-difluorophenyl)propionic acid, Boc-Phe(3,5-DiF)-OH
CAS Number
205445-52-9
Purity
≥ 99% (HPLC)
Molecular Formula
C14H17F2NO4
Molecular Weight
301.3
MDL Number
MFCD00797555
PubChem ID
21865921
Melting Point
109-115 °C
Appearance
White to off-white powder
Optical Rotation
[a]D25 = -31 ± 2º (C=1 in DMF)
Conditions
Store at 0-8 °C
Properties
Additional property information coming soon!
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Safety and Regulations
Hazmat
No
Antibiotic
No
DEA-regulated
No
Warnings
-
Applications

Boc-3,5-difluoro-L-phenylalanine is widely utilized in research focused on:

  • Peptide Synthesis: This compound serves as a valuable building block in the synthesis of peptides, particularly in the development of novel therapeutic agents. Its unique fluorinated structure can enhance the stability and bioactivity of peptides.
  • Drug Development: The incorporation of Boc-3,5-difluoro-L-phenylalanine in drug design can lead to improved pharmacokinetic properties, making it a key player in the pharmaceutical industry for creating more effective medications.
  • Bioconjugation: This chemical is used in bioconjugation processes to attach biomolecules to drugs or imaging agents, enhancing their targeting capabilities and efficacy in treatments.
  • Research in Cancer Therapeutics: Its application in cancer research allows scientists to explore new avenues for targeted therapies, particularly in designing compounds that can selectively target cancer cells.
  • Fluorine-Containing Compounds: The presence of fluorine in this compound can improve the lipophilicity of drugs, which is advantageous in various medicinal chemistry applications, providing a competitive edge over non-fluorinated analogs.

Citations