Discover the new Chem-Impex: Where innovation starts with a bond.

Catalog Number:
05348
CAS Number:
112380-10-6
Nα-Fmoc-Nim-4-toluenesylfonyl-L-histidine
Purity:
≥ 99% (Chiral HPLC, HPLC, TLC)
Synonym(s):
Fmoc-L-His(Tos)-OH
Documents
$35.00 /1G
Pack Size Availability Price
Request Bulk Quote
Product Information

Na-Fmoc-Nim-4-toluenesylfonyl-L-histidine is a versatile amino acid derivative widely utilized in peptide synthesis and drug development. This compound features a fluorenylmethoxycarbonyl (Fmoc) protecting group, which is essential for the selective protection of amino groups during the synthesis of peptides. Its unique structure, incorporating a sulfonyl group and an imidazole ring, enhances its reactivity and stability, making it an ideal choice for researchers focusing on complex peptide sequences.

In practical applications, Na-Fmoc-Nim-4-toluenesylfonyl-L-histidine is particularly valuable in the pharmaceutical industry for the development of peptide-based therapeutics. Its ability to facilitate the formation of peptide bonds while maintaining the integrity of sensitive functional groups allows for the synthesis of biologically active compounds. Additionally, this compound can be utilized in the development of targeted drug delivery systems, where precise control over peptide structure is crucial. Researchers appreciate its compatibility with various coupling reagents and its effectiveness in solid-phase peptide synthesis, making it a preferred choice for advancing peptide chemistry.

Synonyms
Fmoc-L-His(Tos)-OH
CAS Number
112380-10-6
Purity
≥ 99% (Chiral HPLC, HPLC, TLC)
Molecular Formula
C28H25N3O6S
Molecular Weight
531.59
MDL Number
MFCD00144353
PubChem ID
4259819
Appearance
White to off-white powder
Optical Rotation
[a]25D = -7 ± 1 ° (C=1 in DMF)
Conditions
Store at 0 - 8 °C
General Information
Synonyms
Fmoc-L-His(Tos)-OH
CAS Number
112380-10-6
Purity
≥ 99% (Chiral HPLC, HPLC, TLC)
Molecular Formula
C28H25N3O6S
Molecular Weight
531.59
MDL Number
MFCD00144353
PubChem ID
4259819
Appearance
White to off-white powder
Optical Rotation
[a]25D = -7 ± 1 ° (C=1 in DMF)
Conditions
Store at 0 - 8 °C
Properties
Additional property information coming soon!
-
Safety and Regulations
Hazmat
No
Antibiotic
No
DEA-regulated
No
Warnings
-
Applications

Na-Fmoc-Nim-4-toluenesylfonyl-L-histidine is widely utilized in research focused on:

  • Peptide Synthesis: This compound serves as a key building block in the synthesis of peptides, allowing researchers to create complex structures for various applications in drug development and biotechnology.
  • Drug Discovery: It plays a crucial role in the design of novel therapeutic agents, particularly in targeting specific biological pathways, enhancing the efficacy of potential drugs.
  • Bioconjugation: The chemical is used in bioconjugation processes, facilitating the attachment of biomolecules to drugs or imaging agents, which improves their targeting and effectiveness.
  • Research in Cancer Therapeutics: Its unique properties make it valuable in cancer research, where it can be utilized to develop targeted therapies that minimize side effects while maximizing treatment efficacy.
  • Protein Engineering: This compound aids in the modification of proteins, enabling scientists to enhance their stability and functionality for various industrial and therapeutic applications.

Citations