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Catalog Number:
05701
CAS Number:
268729-12-0
Fmoc-O-tert-butyl-D-trans-4-hydroxyproline
Purity:
≥ 98% (HPLC)
Synonym(s):
Fmoc-D-Hyp(tBu)-OH
Documents
$174.96 /100MG
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Product Information

Fmoc-O-tert-butyl-D-trans-4-hydroxyproline is a versatile amino acid derivative widely utilized in peptide synthesis and drug development. This compound features a fluorenylmethoxycarbonyl (Fmoc) protecting group, which is essential for the selective protection of amino groups during the synthesis of peptides. Its unique structure, which includes a tert-butyl group, enhances its stability and solubility, making it an ideal choice for researchers working on complex peptide sequences. The compound's ability to facilitate the synthesis of bioactive peptides allows for advancements in pharmaceutical research, particularly in the development of therapeutics targeting various diseases.

In addition to its role in peptide synthesis, Fmoc-O-tert-butyl-D-trans-4-hydroxyproline has shown potential in the field of materials science, where it can be used to create functionalized polymers and hydrogels. Its compatibility with various coupling reagents and its ability to undergo selective deprotection make it a valuable tool for chemists looking to innovate in drug delivery systems and biomaterials. Researchers and industry professionals will find this compound beneficial for its efficiency and effectiveness in producing high-purity peptides and materials with tailored properties.

Synonyms
Fmoc-D-Hyp(tBu)-OH
CAS Number
268729-12-0
Purity
≥ 98% (HPLC)
Molecular Formula
C24H27NO5
Molecular Weight
409.48
MDL Number
MFCD00798649
PubChem ID
3670482
Appearance
Off-white to pinkish white powder
Optical Rotation
[a]20D = 28 ± 1 ° (C=1 in CHCl3)
Conditions
Store at 0-8°C
General Information
Synonyms
Fmoc-D-Hyp(tBu)-OH
CAS Number
268729-12-0
Purity
≥ 98% (HPLC)
Molecular Formula
C24H27NO5
Molecular Weight
409.48
MDL Number
MFCD00798649
PubChem ID
3670482
Appearance
Off-white to pinkish white powder
Optical Rotation
[a]20D = 28 ± 1 ° (C=1 in CHCl3)
Conditions
Store at 0-8°C
Properties
Additional property information coming soon!
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Safety and Regulations
Hazmat
No
Antibiotic
No
DEA-regulated
No
Warnings
-
Applications

Fmoc-O-tert-butyl-D-trans-4-hydroxyproline is widely utilized in research focused on:

  • Peptide Synthesis: This compound serves as a protective group in the synthesis of peptides, allowing chemists to selectively modify amino acids without affecting others. This is crucial for creating complex peptides used in pharmaceuticals.
  • Drug Development: Its role in stabilizing peptide structures makes it valuable in the development of new drugs, particularly those targeting specific biological pathways. This enhances the efficacy and stability of therapeutic agents.
  • Biotechnology: In the field of biotechnology, it is used to create modified proteins that can be employed in various applications, including enzyme engineering and vaccine development, improving the performance of bioproducts.
  • Research in Neuroscience: The compound is utilized in studies related to neuropeptides, which are important for understanding brain function and developing treatments for neurological disorders.
  • Material Science: It can be incorporated into polymers to enhance their properties, such as flexibility and resistance to degradation, making it useful in creating advanced materials for various industrial applications.

Citations