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Catalog Number:
05724
CAS Number:
174800-02-3
Fmoc-O-benzyl-L-trans-4-hydroxyproline
Purity:
≥ 99% (HPLC)
Synonym(s):
Fmoc-L-Hyp(Bzl)-OH
Documents
$55.40 /1G
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Product Information

Fmoc-O-benzyl-L-trans-4-hydroxyproline is a versatile amino acid derivative widely utilized in peptide synthesis and drug development. This compound features a unique Fmoc (9-fluorenylmethyloxycarbonyl) protecting group, which facilitates the selective modification of amino acids during solid-phase peptide synthesis. Its structural properties, including the benzyl group, enhance its stability and solubility, making it an ideal choice for researchers aiming to create complex peptides with high purity and yield.

In the pharmaceutical industry, Fmoc-O-benzyl-L-trans-4-hydroxyproline is particularly valuable for the synthesis of bioactive peptides, which can serve as potential therapeutics for various diseases. Its ability to incorporate into peptide chains while maintaining the integrity of the peptide backbone allows for the development of novel compounds with improved biological activity. Researchers appreciate its compatibility with various coupling reagents and its ease of deprotection, which streamlines the synthesis process. Overall, this compound stands out for its practical applications in both academic and industrial settings, providing a reliable solution for peptide synthesis challenges.

Synonyms
Fmoc-L-Hyp(Bzl)-OH
CAS Number
174800-02-3
Purity
≥ 99% (HPLC)
Molecular Formula
C27H25NO5
Molecular Weight
443.5
MDL Number
MFCD00237023
PubChem ID
21925010
Melting Point
52 - 54 °C
Appearance
White to off-white powder
Optical Rotation
[a]D20 = -31 ± 2 º (C=1 in DMF)
Conditions
Store at 0 - 8 °C
General Information
Synonyms
Fmoc-L-Hyp(Bzl)-OH
CAS Number
174800-02-3
Purity
≥ 99% (HPLC)
Molecular Formula
C27H25NO5
Molecular Weight
443.5
MDL Number
MFCD00237023
PubChem ID
21925010
Melting Point
52 - 54 °C
Appearance
White to off-white powder
Optical Rotation
[a]D20 = -31 ± 2 º (C=1 in DMF)
Conditions
Store at 0 - 8 °C
Properties
Additional property information coming soon!
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Safety and Regulations
Hazmat
No
Antibiotic
No
DEA-regulated
No
Warnings
-
Applications

Fmoc-O-benzyl-L-trans-4-hydroxyproline is widely utilized in research focused on:

  • Peptide Synthesis: This compound serves as a key building block in the synthesis of peptides, particularly in solid-phase peptide synthesis (SPPS), allowing for the creation of complex peptide structures with high purity.
  • Drug Development: It plays a significant role in the pharmaceutical industry for developing new drugs, especially those targeting protein interactions, due to its ability to mimic natural amino acids.
  • Bioconjugation: The compound is used in bioconjugation processes, where it helps attach biomolecules to surfaces or other molecules, enhancing the functionality of diagnostic and therapeutic agents.
  • Research in Structural Biology: It is valuable in structural biology studies, aiding researchers in understanding protein folding and stability, which is crucial for drug design and development.
  • Cosmetic Formulations: The compound is also explored in cosmetic chemistry for its potential benefits in skin care products, leveraging its properties to improve skin hydration and elasticity.

Citations