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Catalog Number:
07307
CAS Number:
146549-21-5
Fmoc-allyl-L-glycine
Purity:
≥ 99% (HPLC, Chiral HPLC)
Synonym(s):
Fmoc-L-Gly(allyl)-OH, (S)-2-(Fmoc-amino)-4-pentenoic acid, Fmoc-Gly(allyl)-OH
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Product Information

Fmoc-allyl-L-glycine is a versatile amino acid derivative widely utilized in peptide synthesis and drug development. This compound features a fluorenylmethoxycarbonyl (Fmoc) protecting group, which is essential for the selective protection of amino groups during the synthesis of peptides. Its unique allyl side chain enhances the reactivity and versatility of the resulting peptides, making it a valuable building block in the design of bioactive compounds. Researchers in medicinal chemistry and biochemistry often employ Fmoc-allyl-L-glycine to create complex peptide structures that can be used in therapeutic applications, including drug delivery systems and enzyme inhibitors.

The compound's stability under various reaction conditions and its compatibility with standard coupling reagents make it an ideal choice for both academic and industrial laboratories. Additionally, Fmoc-allyl-L-glycine's ability to facilitate the introduction of functional groups allows for the development of novel peptide-based therapeutics. Its application in combinatorial chemistry further expands its utility, enabling the rapid synthesis of diverse peptide libraries for screening in drug discovery processes.

Synonyms
Fmoc-L-Gly(allyl)-OH, (S)-2-(Fmoc-amino)-4-pentenoic acid, Fmoc-Gly(allyl)-OH
CAS Number
146549-21-5
Purity
≥ 99% (HPLC, Chiral HPLC)
Molecular Formula
C20H19NO4
Molecular Weight
337.37
MDL Number
MFCD01311749
PubChem ID
4052587
Melting Point
136 - 139 °C
Appearance
White to off-white powder
Optical Rotation
[a]20D = -8 ± 2 ° (C=1 in DMF)
Conditions
Store at 0 - 8 °C
General Information
Synonyms
Fmoc-L-Gly(allyl)-OH, (S)-2-(Fmoc-amino)-4-pentenoic acid, Fmoc-Gly(allyl)-OH
CAS Number
146549-21-5
Purity
≥ 99% (HPLC, Chiral HPLC)
Molecular Formula
C20H19NO4
Molecular Weight
337.37
MDL Number
MFCD01311749
PubChem ID
4052587
Melting Point
136 - 139 °C
Appearance
White to off-white powder
Optical Rotation
[a]20D = -8 ± 2 ° (C=1 in DMF)
Conditions
Store at 0 - 8 °C
Properties
Additional property information coming soon!
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Safety and Regulations
Hazmat
No
Antibiotic
No
DEA-regulated
No
Warnings
-
Applications

Fmoc-allyl-L-glycine is widely utilized in research focused on

  • Peptide Synthesis: This compound is commonly used as a building block in solid-phase peptide synthesis, allowing researchers to create complex peptides efficiently.
  • Drug Development: Its unique structure makes it valuable in the design of peptide-based therapeutics, particularly in targeting specific biological pathways.
  • Bioconjugation: The allyl group facilitates bioconjugation processes, enabling the attachment of peptides to various biomolecules for enhanced drug delivery systems.
  • Research in Neuroscience: It is used in studies investigating neuropeptides, contributing to the understanding of neurological functions and disorders.
  • Custom Synthesis: Laboratories often utilize this compound for custom synthesis projects, providing flexibility in creating tailored compounds for specific research needs.

Citations