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Catalog Number:
12619
CAS Number:
199915-38-3
Fmoc-isothiocyanate
Purity:
≥ 95% (NMR)
Synonym(s):
Fmoc-NCS
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Product Information

Fmoc-isothiocyanate is a versatile reagent widely utilized in organic synthesis and peptide chemistry. This compound, known for its unique protective group functionality, plays a crucial role in the synthesis of peptides and other complex organic molecules. Its ability to selectively react with amines makes it an invaluable tool for researchers aiming to develop novel compounds in pharmaceuticals and biochemistry. Fmoc-isothiocyanate is particularly favored for its stability under various reaction conditions and its ease of removal, allowing for streamlined synthetic processes.

In addition to its applications in peptide synthesis, Fmoc-isothiocyanate is also employed in the development of isothiocyanate derivatives, which have shown potential in medicinal chemistry for their anti-cancer properties. Researchers appreciate its compatibility with solid-phase peptide synthesis, enabling efficient and high-yield production of peptides. The compound's unique properties and practical applications make it an essential reagent for professionals in the fields of organic chemistry and drug development.

Synonyms
Fmoc-NCS
CAS Number
199915-38-3
Purity
≥ 95% (NMR)
Molecular Formula
C16H11NO2S
Molecular Weight
281.3
MDL Number
MFCD01861169
PubChem ID
4154759
Melting Point
36-49 °C
Appearance
Light yellow solid
Conditions
Store at 0-8 °C
General Information
Synonyms
Fmoc-NCS
CAS Number
199915-38-3
Purity
≥ 95% (NMR)
Molecular Formula
C16H11NO2S
Molecular Weight
281.3
MDL Number
MFCD01861169
PubChem ID
4154759
Melting Point
36-49 °C
Appearance
Light yellow solid
Conditions
Store at 0-8 °C
Properties
Additional property information coming soon!
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Safety and Regulations
Hazmat
No
Antibiotic
No
DEA-regulated
No
Warnings
-
Applications

Fmoc-isothiocyanate is widely utilized in research focused on:

  • Peptide Synthesis: It serves as a key reagent in the synthesis of peptides, allowing for the introduction of isothiocyanate groups that can enhance biological activity.
  • Drug Development: This compound is used in the development of pharmaceuticals, particularly in creating compounds that target specific biological pathways, improving efficacy and selectivity.
  • Bioconjugation: Fmoc-isothiocyanate is valuable in bioconjugation processes, where it helps in attaching biomolecules to surfaces or other molecules, facilitating targeted drug delivery.
  • Analytical Chemistry: It is employed in analytical methods to detect and quantify thiols in various samples, aiding in the study of oxidative stress and related conditions.
  • Material Science: The compound finds applications in the development of functional materials, where its unique properties can be harnessed for creating sensors or catalysts.

Citations