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Catalog Number:
12770
CAS Number:
193887-44-4
Fmoc-L-β-homoleucine
Purity:
≥ 98% (HPLC)
Synonym(s):
Fmoc-L-β-HomoLeu-OH, (S)-3-(Fmoc-amino)-5-methyl-hexanoic acid
Documents
$106.96 /250MG
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Product Information

Fmoc-L-b-homoleucine is a versatile amino acid derivative widely utilized in peptide synthesis and drug development. This compound features a fluorenylmethoxycarbonyl (Fmoc) protecting group, which is essential for the selective protection of amino groups during the synthesis of peptides. Its unique structure enhances stability and solubility, making it an ideal choice for researchers focused on developing complex peptide sequences. Fmoc-L-b-homoleucine is particularly valuable in the pharmaceutical industry, where it serves as a building block for bioactive peptides, including those with therapeutic applications in oncology and immunology.

The compound's ability to facilitate the synthesis of peptides with specific structural and functional properties sets it apart from other amino acids. Researchers appreciate its compatibility with various coupling reagents and its effectiveness in solid-phase peptide synthesis (SPPS), allowing for streamlined workflows and improved yields. With its robust performance in peptide synthesis, Fmoc-L-b-homoleucine is an essential tool for scientists aiming to innovate in drug discovery and development.

Synonyms
Fmoc-L-β-HomoLeu-OH, (S)-3-(Fmoc-amino)-5-methyl-hexanoic acid
CAS Number
193887-44-4
Purity
≥ 98% (HPLC)
Molecular Formula
C22H25NO4
Molecular Weight
367.45
MDL Number
MFCD01863059
PubChem ID
4532729
Appearance
White to off-white powder
Optical Rotation
[a]20D = -24 ± 2 ° (C=0.5 in CHCl3)D25 = -5.0 to -7.0º (C=1 in DMF)
Conditions
Store at 0 - 8 °C
General Information
Synonyms
Fmoc-L-β-HomoLeu-OH, (S)-3-(Fmoc-amino)-5-methyl-hexanoic acid
CAS Number
193887-44-4
Purity
≥ 98% (HPLC)
Molecular Formula
C22H25NO4
Molecular Weight
367.45
MDL Number
MFCD01863059
PubChem ID
4532729
Appearance
White to off-white powder
Optical Rotation
[a]20D = -24 ± 2 ° (C=0.5 in CHCl3)D25 = -5.0 to -7.0º (C=1 in DMF)
Conditions
Store at 0 - 8 °C
Properties
Additional property information coming soon!
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Safety and Regulations
Hazmat
No
Antibiotic
No
DEA-regulated
No
Warnings
-
Applications

Fmoc-L-b-homoleucine is widely utilized in research focused on:

  • Peptide Synthesis: This compound serves as a crucial building block in the synthesis of peptides, particularly in solid-phase peptide synthesis (SPPS), allowing for the creation of complex peptide structures with high purity.
  • Drug Development: Its unique properties make it valuable in pharmaceutical research, where it can be incorporated into drug candidates, enhancing their stability and bioavailability.
  • Bioconjugation: Fmoc-L-b-homoleucine is used in bioconjugation processes, linking biomolecules like proteins and antibodies to therapeutic agents, which is essential in targeted drug delivery systems.
  • Research in Protein Engineering: This compound aids in the design of modified proteins, enabling researchers to explore new functionalities and improve existing protein-based therapies.
  • Analytical Chemistry: It is utilized in the development of analytical methods for the characterization of peptides and proteins, providing insights into their structure and function.

Citations