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Catalog Number:
12923
CAS Number:
680-31-9
Hexamethylphosphoramide
Purity:
≥ 99% (GC)
Synonym(s):
Hexamethyl-phosphoric acid tri-amide, HMPA
Hazmat
Documents
$25.20 /100ML
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Product Information

Hexamethylphosphoramide is a versatile and highly effective chemical compound widely utilized in various industrial and research applications. Known for its excellent solvent properties, it serves as a powerful reagent in organic synthesis, particularly in the production of phosphonates and phosphonamides. Its unique structure allows it to act as a strong polar aprotic solvent, making it ideal for facilitating reactions that require a non-protic environment. Researchers often leverage hexamethylphosphoramide in the synthesis of complex organic molecules, enhancing yields and reaction rates.

In addition to its role in organic synthesis, hexamethylphosphoramide is also employed in the field of polymer chemistry, where it acts as a catalyst in the polymerization processes. Its ability to stabilize reactive intermediates makes it a valuable tool for developing new materials with tailored properties. With its broad applicability and effectiveness, hexamethylphosphoramide stands out as an essential compound for professionals seeking reliable solutions in chemical synthesis and material development.

Synonyms
Hexamethyl-phosphoric acid tri-amide, HMPA
CAS Number
680-31-9
Purity
≥ 99% (GC)
Molecular Formula
C6H18N3OP
Molecular Weight
179.2
MDL Number
MFCD00008303
PubChem ID
12679
Melting Point
7°C
Density
1.03 g/mL @ 25 °C
Appearance
Colorless to light yellow liquid
Boiling Point
230-232 °C/740 mmHg
Refractive Index
1.459
Conditions
Store at 0-8 °C
General Information
Synonyms
Hexamethyl-phosphoric acid tri-amide, HMPA
CAS Number
680-31-9
Purity
≥ 99% (GC)
Molecular Formula
C6H18N3OP
Molecular Weight
179.2
MDL Number
MFCD00008303
PubChem ID
12679
Melting Point
7°C
Density
1.03 g/mL @ 25 °C
Appearance
Colorless to light yellow liquid
Boiling Point
230-232 °C/740 mmHg
Refractive Index
1.459
Conditions
Store at 0-8 °C
Properties
Additional property information coming soon!
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Safety and Regulations
Hazmat
Yes
Antibiotic
No
DEA-regulated
No
Warnings
-
Applications

Hexamethylphosphoramide is widely utilized in research focused on:

  • Synthesis of Organophosphorus Compounds: It serves as a versatile reagent in the synthesis of various organophosphorus compounds, which are essential in agriculture and pharmaceuticals.
  • Solvent in Chemical Reactions: This compound acts as a high-polarity solvent, facilitating reactions that require a non-aqueous medium, particularly in organic synthesis.
  • Polymer Chemistry: It is used as a catalyst or additive in the production of polymers, enhancing properties such as thermal stability and mechanical strength.
  • Biochemical Applications: Hexamethylphosphoramide is employed in biochemical research for modifying biomolecules, aiding in the study of enzyme activity and protein interactions.
  • Pharmaceutical Development: Its unique properties make it valuable in drug formulation processes, improving solubility and bioavailability of active pharmaceutical ingredients.

Citations