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Catalog Number:
14014
CAS Number:
139551-74-9
Fmoc-neopentylglycine
Purity:
≥ 98% (HPLC)
Synonym(s):
Fmoc-β-tBu-L-Ala-OH
Documents
$105.00 /250MG
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Product Information

Fmoc-neopentylglycine is a versatile amino acid derivative widely utilized in peptide synthesis and drug development. This compound features a fluorenylmethoxycarbonyl (Fmoc) protecting group, which is essential for the selective protection of amines during the synthesis of peptides. Its unique structure, characterized by a neopentyl side chain, enhances the steric hindrance, making it particularly valuable in the design of peptides with specific conformational properties. Researchers appreciate its ability to improve the solubility and stability of peptides, which is crucial for various applications in pharmaceuticals and biochemistry.

In practical applications, Fmoc-neopentylglycine is often employed in the synthesis of bioactive peptides, where it plays a critical role in modulating biological activity and enhancing therapeutic efficacy. Its use in solid-phase peptide synthesis allows for efficient assembly of complex peptide sequences, making it a preferred choice among chemists and researchers in the field. Additionally, the compound's favorable properties contribute to the development of novel therapeutics, including peptide-based drugs and biomolecules, showcasing its potential in advancing medicinal chemistry and drug discovery.

Synonyms
Fmoc-β-tBu-L-Ala-OH
CAS Number
139551-74-9
Purity
≥ 98% (HPLC)
Molecular Formula
C22H25NO4
Molecular Weight
367.4
MDL Number
MFCD00671389
PubChem ID
4712553
Appearance
White to off-white solid/powder
Optical Rotation
[a]D20 = -22 ± 2 º
Conditions
Store at 0 - 8 °C
General Information
Synonyms
Fmoc-β-tBu-L-Ala-OH
CAS Number
139551-74-9
Purity
≥ 98% (HPLC)
Molecular Formula
C22H25NO4
Molecular Weight
367.4
MDL Number
MFCD00671389
PubChem ID
4712553
Appearance
White to off-white solid/powder
Optical Rotation
[a]D20 = -22 ± 2 º
Conditions
Store at 0 - 8 °C
Properties
Additional property information coming soon!
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Safety and Regulations
Hazmat
No
Antibiotic
No
DEA-regulated
No
Warnings
-
Applications

Fmoc-neopentylglycine is widely utilized in research focused on:

  • Peptide Synthesis: This compound serves as a protective group in solid-phase peptide synthesis, allowing for the selective modification of amino acids without interfering with other functional groups.
  • Drug Development: It plays a role in the development of peptide-based therapeutics, enhancing the stability and bioavailability of drug candidates.
  • Bioconjugation: Fmoc-neopentylglycine can be used to attach peptides to various biomolecules, facilitating the creation of targeted drug delivery systems.
  • Research in Neuroscience: It is utilized in the synthesis of neuropeptides, which are crucial for studying neurological functions and developing treatments for neurological disorders.
  • Custom Peptide Libraries: Researchers use this compound to create diverse peptide libraries for screening potential drug candidates, accelerating the discovery process in pharmaceutical research.

Citations